InChI
1S/C3H6N4S/c1-2-8-3-4-6-7-5-3/h2H2,1H3,(H,4,5,6,7)
SMILES string
CCSc1nnn[nH]1
InChI key
GONFBOIJNUKKST-UHFFFAOYSA-N
type
for DNA synthesis
product line
Proligo Reagents
packaging
pkg of 4 × 2.5 L L0302511-04
concentration
39-43 g/L (titration)
impurities
≤30 ppm water content (Karl Fischer)
color
clear
Quality Level
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General description
ETT activator is an activator solution containing 5-(Ethylthio)-1H-tetrazole – a powerful activator – in acetonitrile. It is mixed with phosphoramidite during the extension step in which it reacts with the amidite group to form a highly reactive intermediate. The intermediate then forms an internucleotide bond with the detritylated 5′hydroxyl group of the growing oligonucleotide chain.
Application
ETT activator has been used in the fast and low-cost synthesis of photolithographic DNA microarrays.
signalword
Danger
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 2 - Skin Irrit. 2
存储类别
3 - Flammable liquids
wgk
WGK 3
flash_point_f
35.6 °F
flash_point_c
2 °C
法规信息
新产品
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Matej Sack et al.
Journal of nanobiotechnology, 14, 14-14 (2016-03-05)
DNA microarrays are a core element of modern genomics research and medical diagnostics, allowing the simple and simultaneous determination of the relative abundances of hundreds of thousands to millions of genomic DNA or RNA sequences in a sample. Photolithographic in
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