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Merck
CN

L0521

脂蛋白A4

ethanol solution

别名:

(5S,6R,15S)-三羟基-(7E,9E,11Z,13E)-二十碳四烯酸

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关于此项目

经验公式(希尔记法):
C20H32O5
化学文摘社编号:
分子量:
352.47
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352211
EC Number:
200-578-6
MDL number:
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InChI key

IXAQOQZEOGMIQS-SSQFXEBMSA-N

InChI

1S/C20H32O5/c1-2-3-8-12-17(21)13-9-6-4-5-7-10-14-18(22)19(23)15-11-16-20(24)25/h4-7,9-10,13-14,17-19,21-23H,2-3,8,11-12,15-16H2,1H3,(H,24,25)/b6-4-,7-5+,13-9+,14-10+/t17-,18+,19-/m0/s1

SMILES string

CCCCC[C@H](O)\C=C\C=C/C=C/C=C/[C@@H](O)[C@@H](O)CCCC(O)=O

form

ethanol solution

shipped in

dry ice

storage temp.

−20°C

Quality Level

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Biochem/physiol Actions

脂蛋白A4(LXA4)由花生四烯酸合成,是一种内源性脂氧合酶衍生的类花生酸介体。它是一种有效的人蛋白激酶C激活剂。它抑制自然杀伤细胞的细胞毒性。LXA4调节免疫系统和炎症。在大脑中,它调节神经元信号传导和慢波睡眠。LXA4与大麻素受体结合。LXA4在子宫内膜和生殖功能的维持中起关键作用。LXA4的消耗有助于囊性纤维化(CF)的病理生理。

Packaging

氩气包装。

pictograms

FlameExclamation mark

signalword

Danger

hcodes

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2

存储类别

3 - Flammable liquids

wgk

WGK 2

flash_point_f

55.4 °F

flash_point_c

13 °C

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

法规信息

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分析证书(COA)

Lot/Batch Number

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The lipoxin receptor ALX: potent ligand-specific and stereoselective actions in vivo.
Chiang N, et al.
Pharmacological Reviews, 58(3), 463-487 (2006)
Ioannis Kourtzelis et al.
Nature immunology, 20(1), 40-49 (2018-11-21)
Resolution of inflammation is essential for tissue homeostasis and represents a promising approach to inflammatory disorders. Here we found that developmental endothelial locus-1 (DEL-1), a secreted protein that inhibits leukocyte-endothelial adhesion and inflammation initiation, also functions as a non-redundant downstream
Romain A Colas et al.
Infection and immunity, 86(4) (2018-01-24)
Trypanosoma cruzi is a protozoan parasite that causes Chagas disease (CD). CD is a persistent, lifelong infection affecting many organs, most notably the heart, where it may result in acute myocarditis and chronic cardiomyopathy. The pathological features include myocardial inflammation
Lipoxin A4 and its analog suppress inflammation by modulating HMGB1 translocation and expression in psoriasis.
Liu X, et al.
Scientific Reports, 7(1), 7100-7100 (2017)
Stephanie G Dakin et al.
Scientific reports, 7(1), 11009-11009 (2017-09-10)
The mechanisms underpinning the failure of inflammation to resolve in diseased musculoskeletal soft tissues are unknown. Herein, we studied bioactive lipid mediator (LM) profiles of tendon-derived stromal cells isolated from healthy donors and patients with chronic tendinopathy. Interleukin(IL)-1β treatment markedly

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