L0879
Leu-Leu-Leu
≥90% (elemental analysis), suitable for mass spectrometry (MS)
别名:
Trileucine
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关于此项目
经验公式（希尔记法）:
C18H35N3O4
化学文摘社编号:
分子量:
357.49
MDL编号:
UNSPSC代码:
12352202
PubChem化学物质编号:
NACRES:
NA.26
产品名称
Leu-Leu-Leu, ≥90% (elemental analysis)
质量水平
方案
≥90% (elemental analysis)
表单
powder
技术
electron microscopy: suitable
mass spectrometry (MS): suitable
颜色
white
储存温度
−20°C
SMILES字符串
CC(C)CC(N)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(O)=O
InChI
1S/C18H35N3O4/c1-10(2)7-13(19)16(22)20-14(8-11(3)4)17(23)21-15(18(24)25)9-12(5)6/h10-15H,7-9,19H2,1-6H3,(H,20,22)(H,21,23)(H,24,25)
InChI key
DNDWZFHLZVYOGF-UHFFFAOYSA-N
Amino Acid Sequence
Leu-Leu-Leu
应用
Trileucine (Leu-Leu-Leu), an endosome escape moiety, may be used for pH-dependent endosomal membrane disruption to release agents such as antisense oligonucleotides (AONs) inside cells. Trileucine is used to evaluate the absorption characteristics of reversed phase liquid chromatography (HPLC) media.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
动植物源性产品
此项目有
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Proceedings of the National Academy of Sciences of the United States of America, 107(42), 18143-18148 (2010-10-06)
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Hui Ding et al.
Biomaterials, 34(1), 217-225 (2012-10-16)
Anionic polymers are valuable components used in cosmetics and health sciences, especially in drug delivery, because of their chemical versatility and low toxicity. However, because of their highly negative charge they pose problems for penetration through hydrophobic barriers such as
Anna Andrzejewska et al.
Journal of chromatography. A, 1216(18), 3992-4004 (2009-03-31)
The single-component equilibrium adsorption of the tripeptide Leucyl-Leucyl-Leucine (LLL) on a high-efficiency Jupiter Proteo column (C(12)) was investigated experimentally and modeled theoretically. The experimental equilibrium isotherms of LLL for adsorption on a C(12) packing material from an aqueous solution of
Rameshwar Patil et al.
Pharmaceutical research, 27(11), 2317-2329 (2010-04-14)
Temozolomide (TMZ) is a pro-drug releasing a DNA alkylating agent that is the most effective drug to treat glial tumors when combined with radiation. TMZ is toxic, and therapeutic dosages are limited by severe side effects. Targeted delivery is thus
S A Adibi et al.
Metabolism: clinical and experimental, 32(2), 103-105 (1983-02-01)
When baboons, while consuming an adequate diet, were infused continuously for 3 days with parenteral solutions (1I/day) containing either triglycine (50 mM) or trileucine (5 mM) there was either no or very little accumulation of these peptides either in plasma
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