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Merck
CN

L1026

Sigma-Aldrich

利多卡因

Na+ channel blocker, solid

别名:

2-二乙氨基-N-（2,6-二甲苯基）乙酰胺, 利多卡因, 赛洛卡因

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关于此项目

经验公式（希尔记法）:
C14H22N2O
CAS Number:
137-58-6
分子量:
234.34
EC 号:
205-302-8
MDL编号:
MFCD00026733
UNSPSC代码:
12352200
PubChem化学物质编号:
24896272
NACRES:
NA.77

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Product Name

利多卡因, analytical standard

等级

analytical standard

质量水平

200

表单

solid

包装

vial of 200 mg

技术

HPLC: suitable
gas chromatography (GC): suitable

杂质

≤0.5% Total Organic Impurities (Lidocaine related compound H ≤0.10%


2,6-Dimethylaniline ≤0.01%


Any unspecified impurity ≤0.10%


Total impurities ≤0.5%)

应用

forensics and toxicology
pharmaceutical (small molecule)

SMILES字符串

CCN(CC)CC(=O)Nc1c(C)cccc1C

InChI

1S/C14H22N2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,5-6,10H2,1-4H3,(H,15,17)

InChI key

NNJVILVZKWQKPM-UHFFFAOYSA-N

基因信息

human ... CYP1A2(1544), SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)
rat ... Scnn1a(25122)

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一般描述

Lidocaine is an amide anesthetic, which is used to treat ventricular arrhythmias. It lowers cardiac automaticity and myocardial conduction. Lidocaine inhibits the generation and conduction of nerve impulses. It has an anticonvulsant effect.

应用

Lidocaine has been used to examine its effects in inhibiting lymph flow and protection against envenomation. It has also been used to assess its efficacy as an anti-tussive agent.

生化/生理作用

Na+通道阻滞剂；IB类抗心律失常药。
Na+通道阻滞剂；在肠胃外给药后可迅速被吸收的IB类抗心律失常药。

包装

Supplied in amber screw-cap vials

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SLCF7788
SLBV4350
SLBJ7206V
068K8731
076K8801

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Effect of lidocaine on ventricular arrhythmias in patients with coronary heart disease
Gianelly R, et al.
The New England Journal of Medicine, 277(23), 1215-1219 (1967)
Key Issues in Plastic and Cosmetic Surgery (1999)
Use of within-group designs to test anti-tussive drugs in conscious guinea-pigs
Venkatasamy R, et al.
Journal of Pharmacological and Toxicological Methods, 61(2), 157-162 (2010)
Pharmacological approaches that slow lymphatic flow as a snakebite first aid
van Helden DF, et al.
PLoS Neglected Tropical Diseases, 8(2), e2722-e2722 (2014)
Anesthesiology Keywords Review (2008)
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