L1045
LY-354740 水合物
≥98% (HPLC)
别名:
(1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxy lic acid, Eglumegad, Eglumetad, LY-354740
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关于此项目
经验公式（希尔记法）:
C8H11NO4 · xH2O
分子量:
185.18 (anhydrous basis)
UNSPSC代码:
12352209
eCl@ss:
32160406
NACRES:
NA.77
方案
≥98% (HPLC)
表单
solid
溶解性
deionized water: 8 mg/mL
创始人
Eli Lilly
储存温度
room temp
应用
LY-354740 hydrate has been used as a metabotropic glutamate receptor group II/III agonist to study its behavioral effectsof electric shock on Gammarus fossarum.
生化/生理作用
LY-354740 is a highly selective and potent agonist of group II mGlu (metabotropic glutamate) receptors.
LY-354740 is a highly selective and potent agonist of group II mGlu (metabotropic glutamate) receptors. It displays antianxiety and antiaddictive activity in vivo. It?s orally and systemically active. It is anxiolytic and inhibits symptoms of morphine withdrawal in morphine-dependent mice.
特点和优势
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Marie-Jeanne Perrot-Minnot et al.
Royal Society open science, 4(12), 171558-171558 (2018-01-09)
Anxiety is an emotional state generally expressed as sustained apprehension of the environment and elevated vigilance. It has been widely reported in vertebrates and, more recently, in a few invertebrate species. However, its fitness value remains elusive. We investigated anxiety-like
Anxiety-like behaviour increases safety from fish predation in an amphipod crustacea
Perrot M M, et al.
Royal Society open science, 4(12), 171558-171558 (2017)
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