L106
Loxapine succinate salt
solid
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关于此项目
经验公式（希尔记法）:
C18H18ClN3O · C4H6O4
化学文摘社编号:
分子量:
445.90
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
248-682-0
MDL number:
Form:
solid
Quality level:
InChI key
YQZBAXDVDZTKEQ-UHFFFAOYSA-N
InChI
1S/C18H18ClN3O.C4H6O4/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18;5-3(6)1-2-4(7)8/h2-7,12H,8-11H2,1H3;1-2H2,(H,5,6)(H,7,8)
SMILES string
CN(CC1)CCN1C2=NC3=C(C=CC=C3)OC4=C2C=C(Cl)C=C4.OC(CCC(O)=O)=O
form
solid
color
white
solubility
H2O: soluble
originator
Watson
Quality Level
Gene Information
human ... DRD2(1813), DRD3(1814), DRD4(1815), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR7(3363)
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Biochem/physiol Actions
D2/D4 dopamine receptor antagonist; 5-HT2A/2B, 5-H7 serotonin receptor antagonist; dibenzoxazepine antipsychotic agent.
Features and Benefits
This compound was developed by Watson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Robert H Howland
Journal of psychosocial nursing and mental health services, 50(1), 16-18 (2012-01-11)
Acute agitation in patients with schizophrenia or bipolar disorder is an important clinical management problem. Liquid concentrates, orally disintegrating tablets, and/or intramuscular formulations of several second-generation atypical antipsychotic drugs are available for treating acute agitation. Loxapine is an older first-generation
[Progress through formulation].
Heike Oberpichler-Schwenk
Medizinische Monatsschrift fur Pharmazeuten, 36(7), 243-243 (2013-08-01)
B L Roth et al.
Psychopharmacology, 120(3), 365-368 (1995-08-01)
The affinities of 13 atypical and 12 typical antipsychotic drugs for the cloned rat D4 dopamine receptor and the D4/D2 ratios were examined. Of the atypical antipsychotic drugs tested, only clozapine, risperidone, olanzapine, zotepine and tiospirone had affinities less than
E Glusa et al.
British journal of pharmacology, 130(3), 692-698 (2000-05-24)
The endothelial 5-HT receptor mediating relaxation of pig pulmonary artery has been characterized using the selective 5-HT(2B) receptor agonist BW 723C86 and a variety of structurally diverse 5-HT receptor antagonists. If arterial rings with intact endothelium were precontracted with prostaglandin
R T Owen
Drugs of today (Barcelona, Spain : 1998), 49(3), 195-201 (2013-03-26)
The treatment of acute agitation in psychiatric patients has traditionally involved the use of oral or intramuscular benzodiazepines, antipsychotics or their combination. However, oral medication may have too slow an onset and while the intramuscular route is faster, it carries
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