L106
Loxapine succinate salt
solid
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关于此项目
经验公式（希尔记法）:
C18H18ClN3O · C4H6O4
化学文摘社编号:
分子量:
445.90
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
248-682-0
MDL number:
Form:
solid
Quality level:
form
solid
Quality Level
color
white
solubility
H2O: soluble
originator
Watson
SMILES string
CN(CC1)CCN1C2=NC3=C(C=CC=C3)OC4=C2C=C(Cl)C=C4.OC(CCC(O)=O)=O
InChI
1S/C18H18ClN3O.C4H6O4/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18;5-3(6)1-2-4(7)8/h2-7,12H,8-11H2,1H3;1-2H2,(H,5,6)(H,7,8)
InChI key
YQZBAXDVDZTKEQ-UHFFFAOYSA-N
Gene Information
human ... DRD2(1813), DRD3(1814), DRD4(1815), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR7(3363)
Biochem/physiol Actions
D2/D4 dopamine receptor antagonist; 5-HT2A/2B, 5-H7 serotonin receptor antagonist; dibenzoxazepine antipsychotic agent.
Features and Benefits
This compound was developed by Watson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Robert H Howland
Journal of psychosocial nursing and mental health services, 50(1), 16-18 (2012-01-11)
Acute agitation in patients with schizophrenia or bipolar disorder is an important clinical management problem. Liquid concentrates, orally disintegrating tablets, and/or intramuscular formulations of several second-generation atypical antipsychotic drugs are available for treating acute agitation. Loxapine is an older first-generation
B L Roth et al.
Psychopharmacology, 120(3), 365-368 (1995-08-01)
The affinities of 13 atypical and 12 typical antipsychotic drugs for the cloned rat D4 dopamine receptor and the D4/D2 ratios were examined. Of the atypical antipsychotic drugs tested, only clozapine, risperidone, olanzapine, zotepine and tiospirone had affinities less than
[Progress through formulation].
Heike Oberpichler-Schwenk
Medizinische Monatsschrift fur Pharmazeuten, 36(7), 243-243 (2013-08-01)
Andrea Reed et al.
Drug metabolism letters, 6(1), 26-32 (2012-02-04)
The antipsychotic drugs risperidone, paliperidone, olanzapine, quetiapine, aripiprazole, clozapine, haloperidol, and chlorpromazine have been reported to have various degrees of interaction (substrate or inhibitor) with the multidrug resistance transporter, P-glycoprotein (P-gp). An interaction of the antipsychotic drug loxapine with P-gp
H O Kalkman et al.
British journal of pharmacology, 124(7), 1550-1556 (1998-09-02)
1. The mechanism underlying the anticataleptic properties of the atypical neuroleptic agent, clozapine, has been investigated in the rat. 2.The close structural analogues of clozapine, loxapine (0.1 mg kg(-1) s.c.) and iso-clozapine (1 and 3 mg kg(-1) s.c.) induced catalepsy
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| L106-100MG | 04061832091679 |
| L106-500MG | 04061833949214 |
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