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About This Item
经验公式（希尔记法）:
C21H19F3N2O4SHCl
CAS Number:
分子量:
488.91
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
off-white
溶解性
DMSO: >20 mg/mL
创始人
Eli Lilly
储存温度
2-8°C
SMILES字符串
Cl.COc1ccccc1Oc2ccc(cc2)N(Cc3cccnc3)S(=O)(=O)CC(F)(F)F
InChI
1S/C21H19F3N2O4S.ClH/c1-29-19-6-2-3-7-20(19)30-18-10-8-17(9-11-18)26(14-16-5-4-12-25-13-16)31(27,28)15-21(22,23)24;/h2-13H,14-15H2,1H3;1H
InChI key
LPWFRDWTOKLHJC-UHFFFAOYSA-N
生化/生理作用
LY-487379 is a positive allosteric modulator of the metabotropic glutamate receptor mGluR2.
LY-487379 is a positive allosteric modulator of the metabotropic glutamate receptor mGluR2. EC50 = 1.7 μM. LY-487379 shows no intrinsic agonist or antagonist activity at hmGluR2 and has no activity at human mGluR3. LY-487379 markedly potentiates glutamate-stimulated [35S]GTPγS binding in a concentration-dependent manner at hmGluR2, shifting the glutamate dose-response curve leftward by 3-fold and increasing the maximum levels of [35S]GTPγS stimulation. LY-487379 has anxiolytic effects in fear-potentiated startle. This activity profile is useful in all symptom domains of schizophrenia.
特点和优势
This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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