L119
L-703,606 草酸盐 水合物
NK-1 tachykinin receptor antagonist, solid
别名:
顺式-2-(二苯基甲基)-N-[(2-碘苯基)甲基]-1-氮杂双环[2.2.2]辛-3-胺 草酸盐
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C27H29IN2 · C2H2O4 · xH2O
化学文摘社编号:
分子量:
598.47 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
L-703,606 草酸盐 水合物, solid
SMILES string
O.OC(=O)C(O)=O.Ic1ccccc1CN[C@@H]2C3CCN(CC3)[C@@H]2C(c4ccccc4)c5ccccc5
InChI
1S/C27H29IN2.C2H2O4.H2O/c28-24-14-8-7-13-23(24)19-29-26-22-15-17-30(18-16-22)27(26)25(20-9-3-1-4-10-20)21-11-5-2-6-12-21;3-1(4)2(5)6;/h1-14,22,25-27,29H,15-19H2;(H,3,4)(H,5,6);1H2/t26-,27-;;/m1../s1
InChI key
NJAUFRHNYIJKDW-AJUXDCMMSA-N
form
solid
storage condition
desiccated
color
white
solubility
DMSO: >10 mg/mL
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 11 mg/mL
H2O: slightly soluble <2 mg/mL
Quality Level
Gene Information
human ... TACR1(6869)
相关类别
Biochem/physiol Actions
强效选择性非肽NK-1速激肽受体拮抗剂。
Disclaimer
吸湿
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
M A Cascieri et al.
Molecular pharmacology, 42(3), 458-463 (1992-09-01)
We have synthesized a potent, selective, radioiodinated antagonist of the human neurokinin-1 (NK1) receptor and have characterized its binding to the cloned receptor expressed in Chinese hamster ovary cells. (cis)-2-(Diphenylmethyl)-N-[(2-iodophenyl)-methyl]-1- azabicyclo[2.2.2]octan-3-amine (L-703606) inhibits binding of 125I-Tyr8-substance P to the human
T M Fong et al.
The Journal of biological chemistry, 267(36), 25664-25667 (1992-12-25)
To identify the molecular determinants of ligand-receptor interactions, the extracellular domain of the human neurokinin-1 receptor was systematically substituted with the corresponding sequences from the other two neurokinin receptor subtypes. Three residues within the first extracellular segment and 2 residues
Ki Bum Um et al.
eLife, 10 (2021-08-20)
Midbrain dopamine (DA) neurons are slow pacemakers that maintain extracellular DA levels. During the interspike intervals, subthreshold slow depolarization underlies autonomous pacemaking and determines its rate. However, the ion channels that determine slow depolarization are unknown. Here we show that
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持