L121
Levallorphan tartrate salt
≥98% (HPLC), powder
别名:
17-(2-Propenyl)morphinan-3-ol tartrate
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经验公式（希尔记法）:
C19H25NO · C4H6O6
化学文摘社编号:
分子量:
433.49
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
200-767-3
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
optical activity
[α]22/D −35°, c = 0.38 in H2O(lit.)
color
white to beige
solubility
H2O: 5 mg/mL, clear
originator
Roche
SMILES string
O[C@H]([C@@H](O)C(O)=O)C(O)=O.[H][C@@]12CCCC[C@@]13CCN(CC=C)[C@@H]2Cc4ccc(O)cc34
InChI
1S/C19H25NO.C4H6O6/c1-2-10-20-11-9-19-8-4-3-5-16(19)18(20)12-14-6-7-15(21)13-17(14)19;5-1(3(7)8)2(6)4(9)10/h2,6-7,13,16,18,21H,1,3-5,8-12H2;1-2,5-6H,(H,7,8)(H,9,10)/t16-,18+,19+;1-,2-/m01/s1
InChI key
FWMLYVACGDQRFU-ZTMWJVNESA-N
Gene Information
human ... OPRD1(4985), OPRM1(4988)
Biochem/physiol Actions
Partial agonist (antagonist) at μ and δ opioid receptors.
Features and Benefits
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Disclaimer
Photosensitive
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
D E Selley et al.
Molecular pharmacology, 51(1), 87-96 (1997-01-01)
G protein activation by different mu-selective opioid agonists was examined in rat thalamus, SK-N-SH cells, and mu-opioid receptor-transfected mMOR-CHO cells using agonist-stimulated guanosine-5'-O-(gamma-thio)-triphosphate ([35S]GTP gamma S) binding to membranes in the presence of excess GDP. [D-Ala2, N-MePhe4, Gly5-ol]Enkephalin (DAMGO) was
Tzu-Pin Li et al.
Scientific reports, 7(1), 10674-10674 (2017-09-08)
This study involved physical and pharmacokinetic characterizations of trans-resveratrol (t-Rev)-loaded saLMPMs which attempted to improve t-Rev's pharmacokinetic profiles and bioavailability resolving hurdles limiting its potential health benefits. The optimal formulation consisted of t-Rev, lecithin, and Pluronic
Ling-Chun Chen et al.
International journal of nanomedicine, 11, 1557-1566 (2016-05-05)
Quercetin (Que) is known to have biological benefits including an anticancer effect, but low water solubility limits its clinical application. The aim of this study was to develop a lecithin-based mixed polymeric micelle (LMPM) delivery system to improve the solubility
Ying-Chen Chen et al.
International journal of nanomedicine, 10, 7265-7274 (2015-12-15)
To alleviate the inherent problems of amphotericin B (AmB), such as poor water solubility and nephrotoxicity, a novel self-assembling mixed polymeric micelle delivery system based on lecithin and combined with amphiphilic polymers, Pluronic(®), Kolliphor(®), d-alpha tocopheryl polyethylene glycol succinate, and
O V Bondar et al.
Acta naturae, 4(1), 78-81 (2012-06-19)
The dynamic light scattering (DLS) technique was applied in order to assess the zeta potential of the plasma membrane of human cells. At pH 7.4, the cell zeta potential for different types of cells showed variations over a wide range
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| L121-5MG | 04061833949238 |
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