质量水平
方案
≥95% (HPLC)
溶解性
H2O: soluble
抗生素抗菌谱
Gram-negative bacteria
Gram-positive bacteria
作用机制
cell membrane | interferes
储存温度
−20°C
Amino Acid Sequence
Arg-Arg-Trp-Gln-Trp-Arg-Met-Lys-Lys-Leu-Gly
一般描述
化学结构：肽
应用
乳铁蛋白B，片段4-14三氟乙酸盐已用于研究乳铁蛋白对人结肠癌细胞增殖的影响。它已被用于研究紫外线介导的人结肠癌细胞DNA损伤。
生化/生理作用
乳铁蛋白B还抑制鼠黑色素瘤和淋巴瘤中的肝和肺转移。此外，它在人类白血病和癌细胞系中引起细胞死亡。对大肠埃希菌、肠炎沙门氏菌、肺炎克雷伯菌、普通变形杆菌、小肠结肠炎耶尔森菌、铜绿假单胞菌、空肠弯曲菌、金黄色葡萄球菌、变形链球菌、白喉棒状杆菌、单核细胞增生李斯特菌和产气荚膜梭菌有效。
初乳和牛奶中的抗菌肽，可防止粘膜表面的细菌感染。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
W Bellamy et al.
The Journal of applied bacteriology, 73(6), 472-479 (1992-12-01)
A physiologically diverse range of Gram-positive and Gram-negative bacteria was found to be susceptible to inhibition and inactivation by lactoferricin B, a peptide produced by gastric pepsin digestion of bovine lactoferrin. The list of susceptible organisms includes Escherichia coli, Salmonella
Liv Tone Eliassen et al.
International journal of cancer, 119(3), 493-500 (2006-03-31)
Antimicrobial peptides have been shown to exert cytotoxic activity towards cancer cells through their ability to interact with negatively charged cell membranes. In this study the cytotoxic effect of the antimicrobial peptide, LfcinB was tested in a panel of human
C Freiburghaus et al.
Journal of dairy science, 92(6), 2477-2484 (2009-05-19)
Food components modify the risk of cancer at a large number of sites but the mechanism of action is unknown. In the present investigation, we studied the effect of the peptide lactoferricin derived from bovine milk lactoferrin on human colon
C Freiburghaus et al.
Journal of dairy science, 95(10), 5552-5560 (2012-08-21)
Treatment of Caco-2 cells with the peptide lactoferricin(4-14), results in reduction of the growth rate by prolongation of the S phase of the cell cycle. Lactoferricin(1-25) is formed in the gut by cleavage from lactoferrin and the bioactive amino acids
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