L1751
亚油酸乙酯
≥99%
别名:
亚麻油酸乙酯
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关于此项目
线性分子式:
CH3(CH2)3(CH2CH=CH)2(CH2)7COOC2H5
化学文摘社编号:
分子量:
308.50
UNSPSC Code:
12352211
NACRES:
NA.25
PubChem Substance ID:
EC Number:
208-868-4
Beilstein/REAXYS Number:
1727827
MDL number:
biological source
plant oil (safflower)
Quality Level
assay
≥99%
form
liquid
refractive index
n20/D 1.455 (lit.)
bp
224 °C/17 mmHg (lit.)
density
0.876 g/mL at 25 °C (lit.)
functional group
ester
lipid type
omega FAs
shipped in
ambient
storage temp.
−20°C
SMILES string
CCCCC\C=C/C\C=C/CCCCCCCC(=O)OCC
InChI
1S/C20H36O2/c1-3-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22-4-2/h8-9,11-12H,3-7,10,13-19H2,1-2H3/b9-8-,12-11-
InChI key
FMMOOAYVCKXGMF-MURFETPASA-N
Application
- Development of self-microemulsifying drug delivery system for oral bioavailability enhancement of berberine hydrochloride.：以亚油酸乙酯为主要成分开发自微乳给药系统(SMEDDS)，提高盐酸小檗碱的口服生物利用度。研究发现生物利用度大幅提高，说明SMEDDS增强水溶性不良药物吸收的作用(Zhu et al., 2013)。
- Metabonomic investigation of liver profiles of nonpolar metabolites obtained from alcohol-dosed rats and mice using high mass accuracy MSn analysis.：研究肝代谢组学以了解酒精加药的生化作用，有用到亚油酸乙酯。亚油酸乙酯用于非极性代谢物分析，以阐明饮酒对肝功能和代谢的影响(Loftus et al., 2011)。
- Enhanced bioavailability of silymarin by self-microemulsifying drug delivery system.：在自微乳给药系统中使用亚油酸乙酯，提高水飞蓟素的生物利用度。研究发现水飞蓟素的吸收和生物利用度增强，说明亚油酸乙酯在药物递送中的有效作用(Wu et al., 2006)。
Biochem/physiol Actions
从三角紫叶酢浆草中分离的亚油酸乙酯能够在小鼠B16黑素瘤细胞中抑制毛喉素诱导的黑色素生成和酪氨酸酶活性。这种抗黑色素生成作用是通过抑制cAMP产生来介导的。
在检测酒精滥用时，亚油酸乙酯可用作定量脂肪酸乙酯（FAEE）的参考物质。可以使用亚油酸乙酯作为乙酰胆碱酯酶（AChE）抑制剂进行研究。
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
235.4 °F - closed cup
flash_point_c
113 °C - closed cup
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Jonathan Kissling et al.
Phytotherapy research : PTR, 19(11), 984-987 (2005-12-01)
In a search for potential acetylcholinesterase (AChE) inhibitors, the ethanol extract of the bulbs of Crinum x powellii (Amaryllidaceae) was found to demonstrate a marked inhibition of this enzyme. Using a bio-guided isolation strategy, linoleic acid ethyl ester has been
Abdulsallam Bakdash et al.
Analytical and bioanalytical chemistry, 396(7), 2469-2477 (2010-02-11)
Fatty acid ethyl esters (FAEE) and ethyl glucuronide (EtG) were determined in 602 meconium samples in a maternal health evaluation study for detection of gestational alcohol consumption. A validated headspace solid phase microextraction method in combination with GC-MS was used
Janine R Hutson et al.
Alcohol (Fayetteville, N.Y.), 45(2), 193-199 (2010-08-14)
Fatty acid ethyl esters (FAEEs) are nonoxidative metabolites of ethanol, and elevated levels of FAEE in meconium are a useful biomarker for heavy prenatal alcohol exposure. FAEE in meconium has been recommended as useful and cost-effective for universal screening for
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| L1751-5G | 04061833949535 |
| L1751-25G | 04061833621219 |
| L1751-1G | 04061833949528 |