L2131
1-硬脂酰-sn-甘油-3-磷酸胆碱
≥99%, powder
别名:
-& # 945;-溶血磷脂酰胆碱,硬脂酰, 溶血卵磷脂,硬脂酰
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关于此项目
经验公式（希尔记法）:
C26H54NO7P
化学文摘社编号:
分子量:
523.68
MDL编号:
UNSPSC代码:
51191904
PubChem化学物质编号:
NACRES:
NA.25
生物来源
synthetic (organic)
质量水平
方案
≥99%
表单
powder
颜色
white
官能团
phospholipid
脂质类型
phosphoglycerides
运输
ambient
储存温度
−20°C
SMILES字符串
O[C@](COP([O-])(OCC[N+](C)(C)C)=O)([H])COC(CCCCCCCCCCCCCCCCC)=O
InChI
1S/C26H55NO7P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-26(29)32-23-25(28)24-34-35(30,31)33-22-21-27(2,3)4/h25,28H,5-24H2,1-4H3,(H,30,31)
InChI key
ARQYPVZFUYHQFR-UHFFFAOYSA-N
应用
<ul>
<li><strong>来源于植物的酚类抑制结构明确（structurally characterised）的蛋白的增多和脂质氧化修饰： </strong> 阐明了1-十八酰基 -sn-甘油-3-磷酰胆碱在防止细胞膜氧化修饰中的作用，该研究与药物递送系统和细胞信号传导研究相关（Soler-Cantero et al., 2012）。</li>
</ul>
<li><strong>来源于植物的酚类抑制结构明确（structurally characterised）的蛋白的增多和脂质氧化修饰： </strong> 阐明了1-十八酰基 -sn-甘油-3-磷酰胆碱在防止细胞膜氧化修饰中的作用，该研究与药物递送系统和细胞信号传导研究相关（Soler-Cantero et al., 2012）。</li>
</ul>
生化/生理作用
1-硬脂酰-sn-甘油-3-磷酸胆碱（LPC，Lyso-PC）用于开发药物透皮给药装置，如脂质体和胶束。它可抑制组蛋白去乙酰化酶3(HDAC3)活性和信号转导和转录活化因子3(STAT3)磷酸化，对慢性髓系白血病(CML)K562细胞具有抗癌作用。
1-硬脂酰-sn-甘油-3-磷酸胆碱（LPC，Lyso-PC）用于开发药物透皮给药装置，如脂质体和胶束。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Marcus O W Grimm et al.
Journal of chromatography. A, 1218(42), 7713-7722 (2011-08-30)
Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by extracellular senile plaques mainly consisting of Aβ, a 40-42 amino acid long peptide, and intracellular neurofibrillary tangles, accompanied by an excessive loss of synapses. Recently evidence accumulated that nutrition, especially
Michał Flasiński et al.
Journal of colloid and interface science, 348(2), 511-521 (2010-05-25)
The interactions of beta-CD with one component monolayers of cholesterol (chol), 1-stearoyl-sn-glycero-3-phosphocholine (lyso-PC), 1,2-dipalmitpyl-sn-phosphocholine (DPPC), sphingomyelin (SM) and the SM/chol and DPPC/chol mixtures have been investigated by the Langmuir monolayer technique and the synchrotron grazing incidence X-ray diffraction (GIXD). The
Ji Hoon Jung et al.
Cell biochemistry and biophysics, 67(3), 1379-1389 (2013-06-04)
We here investigated the anticancer mechanism of 1-stearoyl-sn-glycero-3-phosphocholine (LPC), one of the lysophosphatidylcholines, in chronic myelogenous leukemia (CML) K562 cells. LPC significantly showed cytotoxicity at 80 μM and induced apoptosis by sub-G1 accumulation, increase in Annexin V positive and caspase
Santosh Lamichhane et al.
Scientific data, 5, 180250-180250 (2018-11-14)
Early prediction and prevention of type 1 diabetes (T1D) are currently unmet medical needs. Previous metabolomics studies suggest that children who develop T1D are characterised by a distinct metabolic profile already detectable during infancy, prior to the onset of islet
G M El Maghraby et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 34(4-5), 203-222 (2008-06-24)
The early eighties saw the introduction of liposomes as skin drug delivery systems, initially promoted primarily for localised effects with minimal systemic delivery. Subsequently, a novel ultradeformable vesicular system (termed "Transfersomes" by the inventors) was reported for transdermal delivery with
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