L2407
Luzindole
≥90%, melatonin receptor antagonist
别名:
N-[2-[2-(苯基甲基)-1H-吲哚-3-基]乙基]乙酰胺, N-乙酰基-2-苄基色胺
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关于此项目
经验公式（希尔记法）:
C19H20N2O
化学文摘社编号:
分子量:
292.37
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥90%
Quality level:
产品名称
Luzindole, ≥90%
SMILES string
CC(=O)NCCc1c(Cc2ccccc2)[nH]c3ccccc13
InChI
1S/C19H20N2O/c1-14(22)20-12-11-17-16-9-5-6-10-18(16)21-19(17)13-15-7-3-2-4-8-15/h2-10,21H,11-13H2,1H3,(H,20,22)
InChI key
WVVXBPKOIZGVNS-UHFFFAOYSA-N
assay
≥90%
solubility
DMSO: 5 mg/mL
storage temp.
−20°C
Quality Level
Gene Information
human ... MTNR1A(4543), MTNR1B(4544)
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相关类别
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Naree Song et al.
Journal of pineal research, 53(4), 335-343 (2012-04-28)
Melatonin is an indolamine that is synthesized in the pineal gland and shows a wide range of physiological functions. Although the anti-aging properties of melatonin have been reported in a senescence-accelerated mouse model, whether melatonin modulates cellular senescence has not
Melatonin enhancement of splenocyte proliferation is attenuated by luzindole, a melatonin receptor antagonist
Drazen DL, et al.
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 280(5), R1476-R1482 (2001)
Sameer Gupta et al.
The Journal of steroid biochemistry and molecular biology, 134, 23-36 (2012-10-13)
Immunoenhancing attributes of melatonin (Mel) on the immunocompromised state induced by glucocorticoid is well known, but the involvement of their receptors in the modulation of immunity has never been studied in any rodent. The present study explores the role of
Alicia González et al.
Journal of pineal research, 52(1), 12-20 (2011-07-02)
Melatonin inhibits the genesis and growth of breast cancer by interfering at different levels in the estrogen-signaling pathways. Melatonin inhibits aromatase activity and expression in human breast cancer cells, thus behaving as a selective estrogen enzyme modulator. As the adipose
Exogenous melatonin inhibits neutrophil migration through suppression of ERK activation
Ren DL, et al.
The Journal of Endocrinology, 227(1), 49-60 (2015)
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