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Merck
CN

L2774

林可霉素 盐酸盐

suitable for cell culture, BioReagent

别名:

Methyl 6,8-dideoxy-6-(1-methyl-4-propyl-2-pyrrolidinecarboxamido)-1-thio-D-erythro-α-D-galactooctopyranoside 盐酸盐, 林可霉素 盐酸盐

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关于此项目

经验公式（希尔记法）:
C18H34N2O6S · HCl
化学文摘社编号:
859-18-7
分子量:
443.00
NACRES:
NA.76
PubChem Substance ID:
329817401
UNSPSC Code:
12352207
EC Number:
212-726-7
MDL number:
MFCD00083647
Beilstein/REAXYS Number:
4171650

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产品名称

林可霉素 盐酸盐, BioReagent, suitable for cell culture

potency

800-900 units per mg

InChI key

POUMFISTNHIPTI-BOMBIWCESA-N

InChI

1S/C18H34N2O6S.ClH/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4;/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25);1H/t9-,10-,11+,12-,13+,14-,15-,16-,18-;/m1./s1

SMILES string

Cl.CCC[C@@H]1C[C@H](N(C)C1)C(=O)N[C@H]([C@@H](C)O)[C@H]2O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O

product line

BioReagent

technique(s)

cell culture | mammalian: suitable

color

white to yellow-white

solubility

H2O: 4 mL, clear, colorless to faintly yellow (200 mg + 4 mL H2O)

antibiotic activity spectrum

Gram-positive bacteria

mode of action

protein synthesis | interferes

storage temp.

2-8°C

Quality Level

200

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General description

Chemical structure: macrolide

Application

Lincomycin hydrochloride is an antibiotic used to study the inhibition of protein synthesis, bacterial antibiotic resistance and protein and surfactant binding. It is produced by Streptomyces lincolnensis var. lincolnensis, and has been used in the treatment of Staphylococcal, Streptococcal, and Bacterioides fragilis infections.

Biochem/physiol Actions

作用方式：林可霉素可通过在23S rRNA的肽基转移酶环区域内形成交联来抑制细菌蛋白质的合成。†

抗菌谱：盐酸林可霉素对革兰氏阳性菌有效。

Preparation Note

This product is soluble in water at 50 mg/mL, yielding a clear, colorless solution.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
052K14387
023K06711
096H09775
052K14386

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Liu Duan et al.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 375(1801), 20190402-20190402 (2020-05-05)
Chloroplast-to-nucleus retrograde signalling (RS) is known to impact plant growth and development. In Arabidopsis, we and others have shown that RS affects seedling establishment by inhibiting deetiolation. In the presence of lincomycin, a chloroplast protein synthesis inhibitor that triggers RS
Yongjian Qiu et al.
Nature communications, 10(1), 140-140 (2019-01-13)
Ambient temperature sensing by phytochrome B (PHYB) in Arabidopsis is thought to operate mainly at night. Here we show that PHYB plays an equally critical role in temperature sensing during the daytime. In daytime thermosensing, PHYB signals primarily through the
Phillip A Davis et al.
Photosynthesis research, 112(3), 153-161 (2012-06-15)
Plants use light to fix carbon through the process of photosynthesis but light also causes photoinhibition, by damaging photosystem II (PSII). Plants can usually adjust their rate of PSII repair to equal the rate of damage, but under stress conditions
Kazunori Miyata et al.
Photosynthesis research, 113(1-3), 165-180 (2012-07-17)
When visible light is excess, the photosynthetic machinery is photoinhibited. The extent of net photoinhibition of photosystem II (PSII) is determined by a balance between the rate of photodamage to D1 and some other PSII proteins and the rate of
C F Williams et al.
Journal of environmental quality, 41(5), 1473-1480 (2012-10-27)
The reuse of treated wastewater for groundwater recharge is an effective way to provide advanced treatment and water storage. Contaminants such as human drugs have been identified as a potential problem for use of this water. Gilbert, Arizona maintains a
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商品

Inhibition of Protein Synthesis by Antibiotics

Antibiotics targeting bacterial ribosomes disrupt protein synthesis, a key process in bacterial growth inhibition.

抗生素对蛋白质合成的抑制作用

蛋白质合成是一个复杂、多步骤过程，涉及到很多酶以及构象排列。但是，阻碍细菌蛋白质合成的大部分抗生素对该过程的干扰发生在70S细菌核糖体的30S亚基或50S亚基。

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