产品名称
溶葡球菌酶 来源于溶葡萄球菌, aseptically filled
sterility
aseptically filled
form
powder
specific activity
>500 units/mg protein
mol wt
25 kDa
composition
Protein, 40-70% biuret
antibiotic activity spectrum
Gram-positive bacteria
mode of action
cell wall synthesis | interferes
storage temp.
−20°C
Quality Level
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Biochem/physiol Actions
溶葡萄球菌素是一种分子量约为25 kDa的锌内肽酶。 由于溶葡萄球菌酶能裂解 葡萄球菌 类细胞壁肽聚糖层中的聚甘氨酸交联键，它已被发现可用于细胞裂解，并具有潜在的抗菌治疗作用。
活性最佳pH：约 7.5
活性最佳pH：约 7.5
溶葡萄球菌酶表现出对 金黄色葡萄球菌的溶解作用 。它拥有三种主要酶甘氨酸内肽酶（溶葡萄球菌酶、内切β- N -乙酰基葡萄糖苷酶和 N -乙酸乙酯基- L -丙氨酸酰胺酶）的数种功能。溶葡萄球菌酶可用于治疗耐抗生素的葡萄球菌感染。溶葡萄球菌酶是一种抗葡萄球菌剂，可用作食品工业和临床实验室的防腐剂，用于快速筛查。
General description
化学结构：肽
溶葡萄球菌酶主要以酶原的形式释放出来。在 pH 4 和温度 5℃ 时高度稳定。
Other Notes
在 pH 7.5、37℃、6.0 mL 反应混合液中，1 个单位可在 10 min 内将 金黄色葡萄球菌 细胞混悬液的浊度 (A 620 ) 从 0.250 降至 0.125。
Preparation Note
从L 7386制备
signalword
Danger
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
Lysostaphin: an antistaphylococcal agent
Kumar J K
Applied Microbiology and Biotechnology, 80(4), 555-561 (2008)
Fuying Cui et al.
Drug delivery, 17(8), 617-623 (2010-08-24)
Nasal colonization of Staphylococcus aureus (S.aureus) is known as a significant risk factor for nosocomial infections, and clearance of its nasal colonization greatly reduces the risk. In the present study the preparation and characterizations of the chitosan-o/w cream incorporated with
Igor Belyansky et al.
The Journal of surgical research, 171(2), 409-415 (2011-06-24)
Lysostaphin (LS), a naturally occurring Staphylococcal endopeptidase, has the ability to penetrate biofilm, and has been identified as a potential antimicrobial to prevent mesh infection. The goals of this study were to determine if LS adhered to porcine mesh (PM)
A P Desbois et al.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 30(8), 1015-1021 (2011-02-12)
Drug-resistant staphylococci constitute a serious problem that urgently requires the discovery of new therapeutic agents. There has been a resurgence in interest in using lysostaphin (a specific anti-staphylococcal enzyme) as a treatment for infections caused by these important pathogens. However
M Fenton et al.
Journal of applied microbiology, 111(4), 1025-1035 (2011-08-05)
To develop an efficient purification strategy for the bacteriophage lysin CHAP(K) . To evaluate its antibacterial spectrum(,) enzymatic properties, optimal reaction conditions and lytic activity against live Staphlyococcus aureus. Recombinant CHAP(K) was purified to homogeneity by cation exchange chromatography, with
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