L3880
脂多糖 来源于大肠杆菌 0127:B8
purified by trichloroacetic acid extraction
别名:
LPS
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关于此项目
biological source
Escherichia coli (O127:B8)
Quality Level
form
lyophilized powder
purified by
trichloroacetic acid extraction
impurities
1-10% Protein (Lowry)
shipped in
ambient
storage temp.
2-8°C
General description
本品是从大肠杆菌O127：B8血清型中提取的TCA。来源菌株为ATCC 12740。该LPS血清型已经用于脓毒性休克的研究，并且可在大鼠肾小球masangial细胞中诱导小鼠巨噬细胞和PAF中的NOS合成。
Application
脂多糖（LPS）是革兰氏阴性菌细胞壁的特征组分。LPS及其脂质A部分可通过能够识别常见的病原体相关分子模式（PAMP）的Toll样受体蛋白家族成员Toll样受体4（TLR4）刺激先天性免疫系统细胞。
Biochem/physiol Actions
脂多糖（LPS）位于膜的外层，并且在非包封的菌株中暴露在细胞表面上。它们有助于外膜的完整性，并保护细胞免受胆汁盐和亲脂性抗生素的作用。
Preparation Note
产物可溶于水（5mg/ml）或细胞培养基（1mg/ml），产生浑浊的淡黄色溶液。在经过涡旋，并升温至 70-80oC 后，含水盐水变得更浓缩，但仍然浑浊（20mg/ml）。脂多糖分子在每种溶剂中均形成胶束。在水和磷酸盐缓冲盐水中观察到浑浊的溶液。使用有机溶剂，溶液也是浑浊的。甲醇产生具有漂浮物的浑浊悬浮液，而水则产生均匀浑浊的溶液。
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Claudia Patrignani et al.
Journal of inflammation (London, England), 7, 16-16 (2010-04-01)
PTPH1 is a protein tyrosine phosphatase expressed in T cells but its effect on immune response is still controversial. PTPH1 dephosphorylates TCRzeta in vitro, inhibiting the downstream inflammatory signaling pathway, however no immunological phenotype has been detected in primary T
Mandakh Bekhbat et al.
Brain, behavior, and immunity, 76, 248-257 (2018-12-15)
Adversity during development is a reliable predictor of psychiatric disorders such as depression and anxiety which are increasingly recognized to have an immune component. We have previously demonstrated that chronic adolescent stress (CAS) in rats leads to depressive-like behavior in
Shiu-Ming Kuo et al.
The Journal of nutrition, 135(10), 2411-2416 (2005-09-24)
Sublethal exposure to Escherichia coli endotoxin [lipopolysaccharide (LPS)] attenuates the lethal effects of subsequent insults associated with oxidative stress, such as higher LPS dose, septic peritonitis, and ischemia. Because administration of the antioxidant ascorbate protects against these same insults and
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| L3880-100MG | 04061833272398 |