生物来源
synthetic (organic)
方案
≥98% (HPLC)
表单
solid
溶解性
chloroform: methanol (1:1): 4 mg/mL, clear to slightly hazy, colorless to yellow
运输
wet ice
储存温度
−20°C
基因信息
human ... TOP1(7150)
生化/生理作用
Luotonin A is a cytotoxic alkaloid reported to inhibit topoisomerase I. Luotonin A was originally isolated from the Chinese medicinal plant Paganum nigellastrum. As an antitumor agent, Luotonin A demonstrates cytotoxic activity against the mouse leukemic cell line P-388 at low concentrations (IC50 1.8μg/mL). Luotonin A stabilizes the cleavable human topoisomerase I-DNA binary complex resulting in cytotoxicity to cells (IC50 5.07-12.6 μM).Luotonin forms non-covalent complexes with ds-DNA in the minor groove. It may serve as a prototype for analytical probes of DNA hybridization.
制备说明
Solubility is tested at 4 mg/mL in 1:1 solution of choloform and methanol. Solubility of luotonins in DMSO has been reported.
警示用语：
Danger
危险声明
预防措施声明
危险分类
Acute Tox. 3 Oral
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
监管及禁止进口产品
此项目有
Pierluigi Mussardo et al.
Analytical and bioanalytical chemistry, 400(2), 321-327 (2011-01-19)
The interaction between DNA and several newly synthesized derivatives of the natural anticancer compound luotonin A has been studied. The results from our work reveal an effective and selective alkaloid/double-stranded DNA (ds-DNA) interaction. In the presence of increasing amounts of
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