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Merck
CN

L4395

脂质体试剂盒：用于制备脂质体的脂质混合物

lyophilized powder

别名:

cholesterol, L-α-phosphatidylcholine and stearylamine kit

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关于此项目

UNSPSC Code:
12352211
EC Number:
204-695-3
NACRES:
NA.25

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产品名称

脂质体试剂盒：用于制备脂质体的脂质混合物, lyophilized powder

biological source

egg yolk

form

lyophilized powder

composition

Cholesterol, 9 μmol/package
L-α-Phosphatidylcholine (egg yolk), 63 μmol/package
Stearylamine, 18 μmol/package

functional group

carboxylic acid

shipped in

ambient

storage temp.

−20°C

Quality Level

200

相关类别

Application

脂质体试剂盒用于制备脂质体。

Biochem/physiol Actions

脂质体可用于不同的应用，例如药物递送、诊断、膜模型、疫苗接种佐剂等。这种脂质混合物可用于封装各种低分子量、中等分子量和高分子量的亲水和两亲分子（包括肽、蛋白质以及寡核苷酸和多核苷酸）。
脂质体试剂盒：用于制备脂质体的脂质混合物含有胆固醇；L-α-磷脂酰胆碱和硬脂胺。 脂质体试剂盒可用于制备阳离子（带正电荷）脂质体，用于将材料掺入细胞中。

pictograms

CorrosionEnvironment
GHS05,GHS09

signalword

Danger

hcodes

H318,H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000520760
0000520760
0000509114
0000509114
0000478232

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. I have purchased Product L4395, Liposome Kit.  Is there a difference between positive and negative liposomes?

    The choice is dependent upon what is being encapsulated and how it is being used.  A good reference discussing this question is Ogiso, T., et al., Effect of positively and negatively charged liposomes on skin permeation of drugs. J. Drug Target, 9(1), 49-59 (2001).

  4. How is Product L4395, Liposome Kit, used?

    The Liposomes of a large multilamellar structure type are the most widely used. They can be prepared using Sigma liposome mixtures by concentrating an organic solvent solution of lipids to a thin film on the walls of a container such as by rotary evaporation or by drying in glass with a stream of nitrogen gas. Then, under appropriate conditions, an aqueous solution is added to the thin film and with agitation multilamellar vesicles should form spontaneously with little effort. Large or small unilamellar structured liposomes can also be prepared by varying procedure or conditions. Please see the product insert for Product No. L4031 (the link below) for a step by step protocol that will work for this product also.

  5. How do I prepare the Product L4395, Liposome Kit liposomes?

    Refer to the product information sheet (under Documents, above) for L4031 for preparation information.

  6. I'm thinking of purchasing Product L4395, Liposome Kit.  Why would one use positive vs. negative liposomes?

    Analogous to poly-L-lysine, one may need positively charged agents to deliver drugs to cells, hence positive liposomes.

  7. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  8. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  9. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

G T Köse et al.
Drug delivery, 5(4), 257-264 (1998-01-01)
Multilamellar vesicles (MLV) containing phosphatidyl choline (PC), cholesterol (CHOL), and stearylamine (SA) in the molar ratio of 7:2:0.2 were prepared by the thin film hydration method. Low-molecular-weight heparin (LMWH, MW: 3000) was conjugated with the MLV using carbodiimide (EDC). Infrared
Giulietta Pinato et al.
Journal of biomedical optics, 16(9), 095001-095001 (2011-09-29)
Spatially confined and precise time delivery of neuroactive molecules is an important issue in neurophysiology. In this work we developed a technique for delivering chemical stimuli to cultured neurons consisting in encapsulating the molecules of interest in liposomes. These vectors
Quantification of small extracellular vesicles by size exclusion chromatography with fluorescence detection
Xu R, et al.
Analytical Chemistry, 88(21), 10390-10394 (2016)
Rui Xu et al.
Analytical chemistry, 88(21), 10390-10394 (2016-11-02)
Chemical analysis of small extracellular vesicles (sEVs) circulating in body fluids holds potentials in noninvasive diagnosis of diseases and evaluation of therapeutic treatments. However, quantification of sEVs remains a challenge due to lacking of cost-effective analytical protocols. Herein we report
Sub-Micrometric Liposomes as Drug Delivery Systems in the Treatment and Periodontitis
Di Turi G, et al.
International Journal of Immunopathology and Pharmacology, 25(3), 657-670 (2012)
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