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L4513

[des-Gly¹⁰, D-Ala⁶]-LH-RH ethylamide acetate salt hydrate

Name: [des-Gly<SUP>10</SUP>, <SC>D</SC>-Ala<SUP>6</SUP>]-LH-RH ethylamide acetate salt hydrate
Brand: SIGMA

≥97% (HPLC), LH-RH agonist, powder

别名:

Ethylamide Acetate, Ethylamide Acetate Salt, des-Gly¹⁰ LH-RH

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关于此项目

经验公式（希尔记法）:

C₅₆H₇₈N₁₆O₁₂ · xC₂H₄O₂ · yH₂O

分子量:

1167.32 (anhydrous free base basis)

UNSPSC Code:

12352209

PubChem Substance ID:

329817410

NACRES:

NA.32

MDL number:

MFCD11046043

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产品名称

[des-Gly¹⁰, D-Ala⁶]-LH-RH ethylamide acetate salt hydrate, ≥97% (HPLC), powder

Quality Level

100

assay

≥97% (HPLC)

form

powder

UniProt accession no.

P01148, P13562, P30968, Q01776

storage temp.

−20°C

SMILES string

O.CC(O)=O.CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CO)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](Cc5c[nH]cn5)NC(=O)[C@@H]6CCC(=O)N6

InChI

1S/C56H78N16O12.C2H4O2.H2O/c1-5-60-54(83)45-13-9-21-72(45)55(84)39(12-8-20-61-56(57)58)66-50(79)40(22-30(2)3)67-47(76)31(4)64-49(78)41(23-32-14-16-35(74)17-15-32)68-53(82)44(28-73)71-51(80)42(24-33-26-62-37-11-7-6-10-36(33)37)69-52(81)43(25-34-27-59-29-63-34)70-48(77)38-18-19-46(75)65-38;1-2(3)4;/h6-7,10-11,14-17,26-27,29-31,38-45,62,73-74H,5,8-9,12-13,18-25,28H2,1-4H3,(H,59,63)(H,60,83)(H,64,78)(H,65,75)(H,66,79)(H,67,76)(H,68,82)(H,69,81)(H,70,77)(H,71,80)(H4,57,58,61);1H3,(H,3,4);1H2/t31-,38+,39+,40+,41+,42+,43+,44+,45+;;/m1../s1

InChI key

YEEHIOYEWOESQR-PFHUABGLSA-N

Gene Information

mouse ... GNRH1(2796), GNRHR(2798)
rat ... GNRH1(14714), GNRHR(14715)

Application

[des-Gly10, D-Ala6]-LH-RH ethylamide acetate salt hydrate has been used:

as an luteinizing hormone-releasing hormone (LHRH) agonist to synchronize a cohort of females rats
to synchronize naturally cycling rats
to induce ovulation as a gonadotropin-releasing hormone (GnRH) analogue and as a supplement in Galap extender to dilute qualified ejaculate

Biochem/physiol Actions

Potent LH-RH agonist in rats and mice; reversibly delays sexual maturation in rats, stimulates spawning activity in fish. GnRH ( gonadotropin-releasing hormone, Glp-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2), which is also referred as LHRH (luteinizing hormone-releasing hormone) or gonadorelin, is crucial for mammalian reproduction and is released from hypothalamic neurons. It is responsible for the secretion of gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), from the pituitary glands. Mutations in GnRH are associated with normosmic congenital hypogonadotropic hypogonadism.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

pictograms

GHS08

signalword

Danger

hcodes

H360

pcodes

P201 - P308 + P313

Hazard Classifications

Repr. 1B

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

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全球贸易项目编号

货号	GTIN
L4513-25MG	04061835557554
L4513-1MG	04061835557547
L4513-5MG	04061835557561

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