biological source
Salmonella enterica (Serotype minnesota)
sterility
γ-irradiated
product line
BioXtra
form
lyophilized powder
purified by
gel-filtration chromatography
technique(s)
cell culture | mammalian: suitable
impurities
<1% Protein (Lowry)
storage temp.
2-8°C
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General description
脂多糖（LPS）是革兰氏阴性菌细胞壁的特征性成分。LPS及其脂质A部分可通过Toll样受体4（TLR4）刺激先天免疫系统细胞，TLR4是Toll样受体蛋白家族的成员，它能识别常见的病原体相关分子模式（PAMP）。
Application
来自明尼苏达肠道沙门氏菌血清型的脂多糖用于细胞培养和细胞结合应用。LPS用于诱导人肠上皮细胞和小鼠树突状细胞中NF-κB途径的激活。用于研究自体献血后的免疫应答。
Biochem/physiol Actions
脂多糖（LPS）是革兰氏阴性菌细胞壁的特征性成分。LPS及其脂质A部分可通过Toll样受体4（TLR4）刺激先天免疫系统细胞，TLR4是Toll样受体蛋白家族的成员，它能识别常见的病原体相关分子模式（PAMP）。
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Zsolt Czimmerer et al.
Immunity, 48(1), 75-90 (2018-01-19)
The molecular basis of signal-dependent transcriptional activation has been extensively studied in macrophage polarization, but our understanding remains limited regarding the molecular determinants of repression. Here we show that IL-4-activated STAT6 transcription factor is required for the direct transcriptional repression
R Karger et al.
Transfusion medicine (Oxford, England), 17(1), 45-53 (2007-02-03)
Preoperative autologous blood donation (PABD) has been shown to decrease natural killer (NK) cell function in cancer patients, raising concerns about an increased cancer recurrence risk owing to PABD. It is unclear whether PABD leads to other immunomodulatory effects that
Sumit Bhattacharyya et al.
American journal of physiology. Gastrointestinal and liver physiology, 293(2), G429-G437 (2007-06-02)
Lipopolysaccharide (LPS) is recognized as an inducer of the inflammatory response associated with gram-negative sepsis and systemic inflammatory response syndrome. LPS induction proceeds through Toll-like receptor (TLR) in immune cells and intestinal epithelial cells (IEC). This report presents the first
Kendra Speirs et al.
Journal of immunology (Baltimore, Md. : 1950), 172(2), 752-756 (2004-01-07)
RelB, a member of the NF-kappaB family of transcription factors, is essential for dendritic cell (DC) maturation. Recent findings indicate that RelB is exclusively regulated through its interaction with cytoplasmic NF-kappaB2/p100. The studies presented in this report show that DCs
Junfeng Zhang et al.
Anesthesiology, 121(4), 773-785 (2014-09-25)
Postoperative cognitive dysfunction is a clinical entity that is associated with poor outcome. We determined the effectiveness of amantadine in reducing surgery-induced cognitive impairment and the role of glial cell line-derived neurotrophic factor (GDNF) in this effect. Four-month old male
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