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L4897

Luteinizing hormone releasing hormone salmon

≥97% (HPLC)

别名:

GnRH, Gonadoliberin, Gonadotropin releasing hormone, LH-RH

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关于此项目

经验公式（希尔记法）:
C60H73N15O13
化学文摘社编号:
86073-88-3
分子量:
1212.31
NACRES:
NA.32
PubChem Substance ID:
24896381
UNSPSC Code:
51111800
MDL number:
MFCD00133497
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Quality Level

200

assay

≥97% (HPLC)

UniProt accession no.

P55248, P01148, P07490, P13562, P30968, P30969, Q01776

storage temp.

−20°C

SMILES string

CC(C)CC(NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)C(Cc3ccc(O)cc3)NC(=O)C(CO)NC(=O)C(Cc4c[nH]c5ccccc45)NC(=O)C(Cc6cnc[nH]6)NC(=O)C7CCC(=O)N7)C(=O)N8CCCC8C(=O)NCC(N)=O

InChI

1S/C60H73N15O13/c1-32(2)20-47(60(88)75-19-7-12-49(75)59(87)65-28-50(61)78)73-55(83)44(22-34-25-63-40-10-5-3-8-38(34)40)69-52(80)29-66-53(81)43(21-33-13-15-37(77)16-14-33)70-58(86)48(30-76)74-56(84)45(23-35-26-64-41-11-6-4-9-39(35)41)71-57(85)46(24-36-27-62-31-67-36)72-54(82)42-17-18-51(79)68-42/h3-6,8-11,13-16,25-27,31-32,42-49,63-64,76-77H,7,12,17-24,28-30H2,1-2H3,(H2,61,78)(H,62,67)(H,65,87)(H,66,81)(H,68,79)(H,69,80)(H,70,86)(H,71,85)(H,72,82)(H,73,83)(H,74,84)

InChI key

NMJREATYWWNIKX-UHFFFAOYSA-N

Gene Information

human ... GNRH1(2796), GNRHR(2798)
mouse ... GNRH1(14714), GNRHR(14715)
rat ... GNRH1(25194), GNRHR(81668)

Application

Luteinizing hormone releasing hormone (salmon) has been used to study the effect of LHRH (luteinizing hormone releasing hormone) in the brain of Podarcis sicula sicula (male) during reproduction. It has been used to study the hormonal regulation of PACAP (pituitary adenylate cyclase-activating polypeptide) and its receptor, PAC1 (adenylate cyclase activating polypeptide 1 (pituitary) receptor type I).

Biochem/physiol Actions

Hypothalamic peptide that stimulates release of gonadotrophins from anterior pituitary, thus regulating reproductive functions.
Stimulates release of gonadotrophins from anterior pituitary.

Other Notes

Lyophilized from 0.5% acetic acid

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H360

Hazard Classifications

Repr. 1B

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000477646
0000477646
0000428464
0000428464
0000321059

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Vasoactive Intestinal Peptide Indirectly Elicits Pituitary LH Secretion Independent of GnRH in Female Zebrafish.
Tanaka, et al.
Endocrinology, 163 (2022)
Weiming Zheng et al.
Reproductive sciences (Thousand Oaks, Calif.), 21(1), 41-51 (2013-05-22)
Pituitary adenylate cyclase-activating polypeptide (PACAP) and its receptors are expressed in the hypothalamus, the gonadotrope cells of the anterior pituitary gland, and the gonads, forming an autocrine-paracrine system in these tissues. Within the pituitary, PACAP functions either alone or synergistically
A Gobbetti et al.
Journal of reproduction and fertility, 101(3), 523-529 (1994-08-01)
The release of PGF2 alpha and PGE2, progesterone, androgens and oestradiol in vitro, and the aromatase activity in the brain of the male lizard Podarcis sicula sicula during three different phases of the reproductive period were evaluated. In addition, the
Araceli Diez-Fraile et al.
Human fertility (Cambridge, England), 17(2), 90-98 (2014-04-02)
Reproductive life span and fertility have been shown to depend on successful early folliculogenesis, which involves cell-to-cell communication and the concerted regulation of gene expression at both the oocyte and granulosa cell levels. Recently, micro RNAs (miRNAs) were identified as
Kazue Nagasawa et al.
PloS one, 10(6), e0129571-e0129571 (2015-06-02)
Existing research on the role of gonadotropin-releasing hormone (GnRH) in bivalve reproduction is inadequate, even though a few bivalve GnRH orthologs have been cloned. The objective of this paper was to elucidate the in vivo effect of GnRH administration in
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全球贸易项目编号

货号GTIN
L4897-5MG04061832677156
L4897-1MG04061833957776

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