Leptin Receptor/Fc Chimera from mouse

Leptin receptor is important for regulating appetite and energy expenditure. The neuroendocrine hormone, leptin, works through leptin receptor. In humans and mice, problems in expression of leptin or leptin receptor are associated with obesity.

Leptin receptor (OB-R) is a single membrane-spanning receptor most related to the gp-130 signal-transducing component of the IL-6 receptor, the G-CSF receptor and the LIF receptor. OB-R, also known as B219, is expressed in the yolk sac, early fetal liver, enriched hematopoitic stem cells and in a variety of lymphohematopoietic cell lines. OB-R is also expressed at high levels in adult reproductive organs. OB-RL action in hepatic cells may be equivalent to that of IL-6 receptor. Leptin does not play a specific role in muting insulin action on hepatoma cells and may not contribute to the diabetic symptoms associated with obesity.

Lyophilized from 20 mM Tris containing 5 mg of bovine serum albumin per 100 μg leptin receptor.