L5044
Anti-LXRα (N-terminal) antibody produced in rabbit
~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
Anti-LX receptor, alpha, Anti-LXR-a, Anti-LXRA, Anti-Liver X receptor a, Anti-NR1H3, nuclear receptor subfamily 1 group H, member 3, Anti-RLD-1
产品名称
Anti-LXRα (N-terminal) antibody produced in rabbit, ~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~50 kDa
species reactivity
human
enhanced validation
recombinant expression
Learn more about Antibody Enhanced Validation
concentration
~1.5 mg/mL
technique(s)
western blot: 1-2 μg/mL using HEK-293T cells expressing human LXRα
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... NR1H3(10062)
mouse ... Nr1h3(22259)
rat ... Nr1h3(58852)
Application
Anti-LXRα (N-terminal) antibody produced in rabbit has also been used for western blotting.
Anti-LXRα (N-terminal) antibody produced in rabbit has been used in immunofluorescence.
Biochem/physiol Actions
Liver X receptors (LXRs) heterodimerize with the retinoid X receptor (RXR) and bind to the LXR response element (LXRE). LXRs regulate cholesterol homeostasis by modulating the transcription of genes involved in its catabolism, storage, absorption and transport. Activated LXRs are also potent inhibitors of inflammatory responses in macrophages and reduce inflammation in vivo. LXR expression and activation with LXRs ligands have also been shown to modulate atherosclerotic lesions. LXRα/β-deficient mice show enhanced lipid-loaded foam cell accumulation. LXRs have been suggested to play an important role in Alzheimer′s disease (AD) pathogenesis.
The gene LXR α (liver X receptor α) encodes a protein that plays an important role in the control of cholesterol homeostasis. LXRs have been found to regulate inflammatory response in macrophages. They are also involved in the regulation of cell proliferation.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
The gene LXR α (liver X receptor α) is a member of LXRs that belong to the nuclear receptor superfamily. The encoded protein is expressed predominantly in macrophages, liver, intestine, kidney, lung and adipose tissue. The gene is mapped to human chromosome 11p11.2. The protein contains a DNA-binding domain that requires the ligand-binding domain to heterodimerize with a retinoid X receptor partner for its DNA-binding activity.
The liver X receptors (LXRs) are encoded by two different genes, LXRα (NR1H3) and LXRβ (NR1H2). LXRα expression is restricted to macrophages and tissues involved in lipid metabolism.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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存储类别
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
Liver X receptors as integrators of metabolic and inflammatory signaling
Zelcer N and Tontonoz P
The Journal of Clinical Investigation, 116(3), 607-614 (2006)
Gang Wang et al.
Cell death & disease, 12(3), 254-254 (2021-03-12)
C1q tumor necrosis factor-related protein 12 (CTRP12), a conserved paralog of adiponectin, is closely associated with cardiovascular disease. However, little is known about its role in atherogenesis. The aim of this study was to examine the influence of CTRP12 on
Reciprocal regulation of inflammation and lipid metabolism by liver X receptors
Joseph SB, et al.
Nature Medicine, 9(2), 213-213 (2003)
Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors
Zelcer N, et al.
Proceedings of the National Academy of Sciences of the USA, 104(25), 10601-10606 (2007)
Identification of macrophage liver X receptors as inhibitors of atherosclerosis
Tangirala RK, et al.
Proceedings of the National Academy of Sciences of the USA, 99(18), 11896-11901 (2002)
相关内容
Instructions
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