生物来源
synthetic (organic)
方案
≥98%
表单
solid
溶解性
chloroform/methanol (4:1): 2 mg/mL, clear to slightly hazy, colorless to yellow
运输
wet ice
储存温度
−20°C
基因信息
human ... TOP1(7150)
一般描述
Luotonin B is a heteroaromatic pyrroloquinazolinoquinoline alkaloid that, along with Luotonin A and E, was originally isolated from the Chinese medicinal plant Paganum nigellastrum. It is an oxidation product of Luotonin A and is converted to Luotonin E by methanol treatment.
生化/生理作用
Luotonin compounds have antitumor activity and demonstrate cytotoxicity and inhibitory activity against human topoisomerase. For use as a topoisomerase inhibitor, a starting concentration of 25 μM is suggested. It is suggested that a dose-response curve be performed to find the inhibitor concentration most suitable for the intended assay.
制备说明
Solubility is tested at 2 mg/mL in 4:1 solution of choloform and methanol. Solubility of luotonins in DMSO has been reported.
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Oral
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
涉药品监管产品
此项目有
Recent advances in the studies on luotonins
Liang JL, et al.
Molecules (Basel), 16(6), 4861-4883 (2011)
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