L5139
石蒜碱 盐酸盐
powder, ≥98% (TLC)
别名:
Licorin hydrochloride, Lychorine chloride, Lycorine HCl
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关于此项目
经验公式（希尔记法）:
C16H17NO4 · HCl
化学文摘社编号:
分子量:
323.77
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
石蒜碱 盐酸盐, ≥98% (TLC), powder
Quality Level
assay
≥98% (TLC)
form
powder
mp
210-212 °C
solubility
ethanol: 10 mg/mL, clear, colorless to very faintly yellow
storage temp.
2-8°C
SMILES string
Cl.O[C@H]1C=C2CCN3Cc4cc5OCOc5cc4[C@H]([C@@H]1O)[C@@H]23
InChI
1S/C16H17NO4.ClH/c18-11-3-8-1-2-17-6-9-4-12-13(21-7-20-12)5-10(9)14(15(8)17)16(11)19;/h3-5,11,14-16,18-19H,1-2,6-7H2;1H/t11-,14-,15+,16+;/m0./s1
InChI key
VUVNTYCHKZBOMV-NVJKKXITSA-N
Biochem/physiol Actions
A selective inhibitor of peptidyl transferase center (PTC).
A selective inhibitor of peptidyl transferase center (PTC). In HL-60 (leukemia) cells, lycorine arrests the cell cycle at G2/M and induces apoptosis by a caspase-mediated pathway.
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
涉药品监管产品
此项目有
Jingjing Kang et al.
International immunopharmacology, 12(1), 249-256 (2011-12-14)
As a natural alkaloid extracted from Amaryllidaceae, lycorine shows various biological effects on tumor cells. Here we show that lycorine dose-dependently inhibited the LPS-induced up-regulation of nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein level in RAW264.7 cells. Besides, it
Carolyn Botting et al.
Expert opinion on drug discovery, 7(5), 417-428 (2012-03-24)
The members of the family Flaviviridae, including West Nile virus, yellow fever virus and dengue virus, are important human pathogens that are expanding their impact around the globe. The four serotypes of dengue infect 50-100 million people each year, yet
Ivan Ivanov et al.
Journal of plant physiology, 169(2), 206-211 (2011-11-29)
The alkaloid patterns in Leucojum aestivum L. shoot culture cultivated at temporary immersion conditions were investigated using gas chromatography-mass spectrometry. 18 alkaloids were identified, and galanthamine, hamayne and lycorine were dominant. The L. aestivum 80 shoot culture, cultivated at temporary
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| L5139-20MG | 04061833957905 |