L5139
石蒜碱 盐酸盐
powder, ≥98% (TLC)
别名:
Licorin hydrochloride, Lychorine chloride, Lycorine HCl
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关于此项目
经验公式（希尔记法）:
C16H17NO4 · HCl
化学文摘社编号:
分子量:
323.77
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
石蒜碱 盐酸盐, ≥98% (TLC), powder
Quality Level
assay
≥98% (TLC)
form
powder
mp
210-212 °C
solubility
ethanol: 10 mg/mL, clear, colorless to very faintly yellow
storage temp.
2-8°C
SMILES string
Cl.O[C@H]1C=C2CCN3Cc4cc5OCOc5cc4[C@H]([C@@H]1O)[C@@H]23
InChI
1S/C16H17NO4.ClH/c18-11-3-8-1-2-17-6-9-4-12-13(21-7-20-12)5-10(9)14(15(8)17)16(11)19;/h3-5,11,14-16,18-19H,1-2,6-7H2;1H/t11-,14-,15+,16+;/m0./s1
InChI key
VUVNTYCHKZBOMV-NVJKKXITSA-N
Biochem/physiol Actions
A selective inhibitor of peptidyl transferase center (PTC).
A selective inhibitor of peptidyl transferase center (PTC). In HL-60 (leukemia) cells, lycorine arrests the cell cycle at G2/M and induces apoptosis by a caspase-mediated pathway.
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
涉药品监管产品
此项目有
Jiangning Liu et al.
Virology journal, 8, 483-483 (2011-10-28)
Human enterovirus 71 (EV71) infection causes hand, foot and mouth disease in children under 6 years old and this infection occasionally induces severe neurological complications. No vaccines or drugs are clinical available to control EV71 epidemics. In present study, we
Sascha Kretzing et al.
Archives of toxicology, 85(12), 1565-1573 (2011-06-01)
Lycorine is the main alkaloid of many Amaryllidaceae and known to cause poisoning with still unknown mechanisms. Longer lasting toxicological core symptoms of nausea and emesis may become a burden for human and animal patients and may result in substantial
Raquel Brandt Giordani et al.
Phytochemistry, 72(7), 645-650 (2011-02-18)
In this study, the mechanism of action of the pro-apoptotic alkaloid lycorine on an amitochondriate cell, the parasite Trichomonas vaginalis, was investigated. The cytotoxicity of lycorine against T. vaginalis was studied from 2.5 to 1000μM and several important ultrastructural alterations
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| L5139-20MG | 04061833957905 |