L5288
Latrunculin B
from Latruncula magnifica, ≥80% (HPLC), solid, actin polymerization inhibitor
别名:
LAT-B
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关于此项目
经验公式（希尔记法）:
C20H29NSO5
化学文摘社编号:
分子量:
395.51
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
拉春库林 B 来源于Latruncula magnifica, ≥80% (HPLC), solid
质量水平
方案
≥80% (HPLC)
表单
solid
分子量
395.5
溶解性
ethanol: soluble
储存温度
−20°C
SMILES字符串
C[C@H]1CC[C@@H]2C[C@H](C[C@@](O)(O2)[C@@H]3CSC(=O)N3)OC(=O)C=C(C)CCC=C1
InChI
1S/C20H29NO5S/c1-13-5-3-4-6-14(2)9-18(22)25-16-10-15(8-7-13)26-20(24,11-16)17-12-27-19(23)21-17/h3,5,9,13,15-17,24H,4,6-8,10-12H2,1-2H3,(H,21,23)/b5-3-,14-9-/t13-,15-,16-,17+,20-/m1/s1
InChI key
NSHPHXHGRHSMIK-JRIKCGFMSA-N
一般描述
拉春库林 B是一种大环毒素，由红海海绵（Latruncula magnifica ）产生。
应用
来自红海海绵（Latruncula magnifica ）的拉春库林 B在各种实验中用于肌动蛋白解聚。它还被用作骨髓来源树突状细胞 （BMDC）完全培养基中的一种成分，用于研究树突状细胞中吞噬体小管的形成。
生化/生理作用
拉春库林B 在体外抑制肌动蛋白聚合。拉春库林B破坏了微丝介导的过程。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
高风险级别生物产品--病毒，疫苗等
此项目有
Steven L Jones et al.
The Journal of cell biology, 205(1), 67-81 (2014-04-09)
The axon initial segment (AIS) of differentiated neurons regulates action potential initiation and axon-dendritic polarity. The latter function depends on actin dynamics, but actin structure and functions at the AIS remain unclear. Using platinum replica electron microscopy (PREM), we have
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Vukavsinovic N, et al.
The New phytologist, 213(3), 1052-1067 (2017)
Li-Kun Phng et al.
Development (Cambridge, England), 140(19), 4031-4040 (2013-09-21)
Actin filaments are instrumental in driving processes such as migration, cytokinesis and endocytosis and provide cells with mechanical support. During angiogenesis, actin-rich filopodia protrusions have been proposed to drive endothelial tip cell functions by translating guidance cues into directional migration
Visualizing toll-like receptor-dependent phagosomal dynamics in murine dendritic cells using live cell microscopy
Mantegazza AR and Marks MS
Methods in Molecular Biology, 191-203 (2015)
Synthesis of Essential Drugs (2012)
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