L5288
Latrunculin B
from Latruncula magnifica, ≥80% (HPLC), solid, actin polymerization inhibitor
别名:
LAT-B
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关于此项目
经验公式（希尔记法）:
C20H29NSO5
化学文摘社编号:
分子量:
395.51
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
拉春库林 B 来源于Latruncula magnifica, ≥80% (HPLC), solid
SMILES string
C[C@H]1CC[C@@H]2C[C@H](C[C@@](O)(O2)[C@@H]3CSC(=O)N3)OC(=O)C=C(C)CCC=C1
InChI key
NSHPHXHGRHSMIK-JRIKCGFMSA-N
InChI
1S/C20H29NO5S/c1-13-5-3-4-6-14(2)9-18(22)25-16-10-15(8-7-13)26-20(24,11-16)17-12-27-19(23)21-17/h3,5,9,13,15-17,24H,4,6-8,10-12H2,1-2H3,(H,21,23)/b5-3-,14-9-/t13-,15-,16-,17+,20-/m1/s1
assay
≥80% (HPLC)
form
solid
mol wt
395.5
solubility
ethanol: soluble
storage temp.
−20°C
Quality Level
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相关类别
General description
拉春库林 B是一种大环毒素，由红海海绵（Latruncula magnifica ）产生。
Application
来自红海海绵（Latruncula magnifica ）的拉春库林 B在各种实验中用于肌动蛋白解聚。它还被用作骨髓来源树突状细胞 （BMDC）完全培养基中的一种成分，用于研究树突状细胞中吞噬体小管的形成。
Biochem/physiol Actions
拉春库林B 在体外抑制肌动蛋白聚合。拉春库林B破坏了微丝介导的过程。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
高风险级别生物产品--病毒，疫苗等
此项目有
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The axon initial segment (AIS) of differentiated neurons regulates action potential initiation and axon-dendritic polarity. The latter function depends on actin dynamics, but actin structure and functions at the AIS remain unclear. Using platinum replica electron microscopy (PREM), we have
Synthesis of Essential Drugs (2012)
Li-Kun Phng et al.
Development (Cambridge, England), 140(19), 4031-4040 (2013-09-21)
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