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Merck
CN

L5399

脂质 A，二磷酸酰 来源于大肠杆菌 F583（Rd 突变体）

别名:

二磷酰脂质A（来自大肠杆菌）

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关于此项目

NACRES:
NA.25
PubChem Substance ID:
24896402
UNSPSC Code:
12352211
MDL number:
MFCD00131510

主要文件

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InChI key

GZQKNULLWNGMCW-UHFFFAOYSA-N

SMILES string

CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)C(OCC2OC(OP(O)(O)=O)C(NC(=O)CC(O)CCCCCCCCCCC)C(OC(=O)CC(O)CCCCCCCCCCC)C2O)OC(CO)C1OP(O)(O)=O

InChI

1S/C94H178N2O25P2/c1-7-13-19-25-31-37-38-44-50-56-62-68-84(103)115-78(66-60-54-48-42-35-29-23-17-11-5)72-86(105)119-92-88(96-82(101)71-77(65-59-53-47-41-34-28-22-16-10-4)114-83(102)67-61-55-49-43-36-30-24-18-12-6)93(116-79(73-97)90(92)120-122(107,108)109)113-74-80-89(106)91(118-85(104)70-76(99)64-58-52-46-40-33-27-21-15-9-3)87(94(117-80)121-123(110,111)112)95-81(100)69-75(98)63-57-51-45-39-32-26-20-14-8-2/h75-80,87-94,97-99,106H,7-74H2,1-6H3,(H,95,100)(H,96,101)(H2,107,108,109)(H2,110,111,112)

biological source

Escherichia coli (F583 Rd mutant)

form

lyophilized powder

shipped in

ambient

storage temp.

2-8°C

Quality Level

200

相关类别

Application

使用脂质A，来自大肠杆菌F583（Rd突变）的焦磷酰：
  • 研究不同脂类A分子对体外肺周细胞增殖的影响
  • 在THP-1和J774A.1细胞，分别形成新蝶呤和亚硝酸盐
  • 在结合实验中用作脂多糖(LPS)衍生物
  • 刺激脾脏细胞并为toll样受体4 (TLR4)的有丝分裂原刺激

Biochem/physiol Actions

脂质A是人体内脂多糖(LPS)强大的免疫刺激活性活动所必需的物质。脂质A是脂多糖的疏水结构域，有助于将脂多糖锚定在细菌的质膜上。它具有免疫活性，是可由免疫系统识别的脂多糖的重要组成部分。

General description

脂质A是脂多糖(LPS)的基本结构，存在于细菌中。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000486028
0000486028
0000406510
0000406510
0000367391

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Cancer research, 39(11), 4756-4759 (1979-11-01)
We described elsewhere that the synergistic antitumor activity of endotoxic extracts from Re mutants of gram-negative bacteria and trehalose mycolate against guinea pig syngeneic line 10 tumor was abrogated after peptide substances accompanying these extracts had been removed. This activity
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This study explores the in vitro relationship between Shiga toxin-producing Shigella spp. and Escherichia coli and the development of vascular complications in humans following bacillary dysentery. We propose that lipopolysaccharide (LPS; endotoxin) may combine with Shiga toxin to facilitate vascular
Progress in the synthesis and biological evaluation of lipid A and its derivatives
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Medicinal Research Reviews, 38(2), 556-601 (2018)
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Attacin is a 20 kDa antibacterial protein, originally isolated from the immune haemolymph of Hyalophora cecropia. It has been demonstrated previously that attacin causes increased permeability of the outer membrane of Escherichia coli and inhibition of outer-membrane protein synthesis at
Activation of complement by endotoxin.
S E Mergenhagen et al.
The Journal of infectious diseases, 128, Suppl:86-Suppl:90 (1973-07-01)
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