L5647
利多卡因 盐酸盐 一水合物
≥99% (HPLC), solid, Na⁺ channel blocker
别名:
2-二乙氨基-N-（2，6-二甲苯基）乙酰胺 盐酸盐 一水合物, 利多卡因 盐酸盐 一水合物, 赛洛卡因 盐酸盐 一水合物
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关于此项目
经验公式（希尔记法）:
C14H22N2O · HCl · H2O
化学文摘社编号:
分子量:
288.81
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
200-803-8
MDL number:
产品名称
利多卡因 盐酸盐 一水合物, solid
InChI
1S/C14H22N2O.ClH.H2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4;;/h7-9H,5-6,10H2,1-4H3,(H,15,17);1H;1H2
InChI key
YECIFGHRMFEPJK-UHFFFAOYSA-N
SMILES string
Cl[H].[H]O[H].CCN(CC)CC(=O)Nc1c(C)cccc1C
form
solid
color
white
solubility
H2O: soluble
Quality Level
Gene Information
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相关类别
Biochem/physiol Actions
Na+ 通道阻滞剂；IB 类抗心律失常药，在肠胃外给药后迅速吸收
Na+ 通道阻滞剂；IB 类抗心律失常药。
Application
Lidocaine hydrochloride monohydrate has been used:
- in the preparation of drug composite for the controlled delivery in vitro, evaluated by drug release profile in ultra-high performance liquid chromatography (UPLC) and as a reference standard for fourier transform infrared spectroscopy (FT-IR).
- to record dose dependent response of sodium voltage (Nav1.7) channels in the injection-molded polymer device.
- For inhibition of glial cells in brain tissue samples.
General description
Lidocaine hydrochloride monohydrate is a commonly used as local anesthetic in topical applications and oral mucosal biopsies. It has a short anesthetic half-life.
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Dennis R Sparta et al.
Nature protocols, 7(1), 12-23 (2011-12-14)
In vivo optogenetic strategies have redefined our ability to assay how neural circuits govern behavior. Although acutely implanted optical fibers have previously been used in such studies, long-term control over neuronal activity has been largely unachievable. Here we describe a
Kristine von Krogh et al.
Biology, 10(11) (2021-11-28)
Zebrafish are often euthanized by overdose of anaesthesia. However, fish may have aversion towards some anaesthetics, and protocol efficacy varies between species. Using wild type adult Danio rerio, we assessed time to loss of opercular beat, righting, and startle reflexes
Ion channel recordings on an injection-molded polymer chip
Tanzi S, et al.
Lab on a chip, 13(24), 4784-4793 (2013)
Päivi Ylä-Anttila et al.
Methods in enzymology, 452, 143-164 (2009-02-10)
Electron microscopy remains one of the most accurate methods for the detection of autophagy and quantification of autophagic accumulation. Compared to fluorescence microscopy, the resolution of transmission electron microscopy is superior. In this chapter we describe the fine structure of
Julie I R Labau et al.
Frontiers in pharmacology, 12, 791740-791740 (2022-01-08)
Lacosamide, developed as an anti-epileptic drug, has been used for the treatment of pain. Unlike typical anticonvulsants and local anesthetics which enhance fast-inactivation and bind within the pore of sodium channels, lacosamide enhances slow-inactivation of these channels, suggesting different binding
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