L6293
LY-364947
≥98% (HPLC), Transforming Growth Factor-β Type I receptor kinase (ALK5) inhibitor, powder
别名:
4-(3-吡啶-2-基-1H-吡唑-4-基)喹啉, HTS 466284, 转化生长因子-β I型受体激酶抑制剂
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关于此项目
经验公式（希尔记法）:
C17H12N4
化学文摘社编号:
分子量:
272.30
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
LY-364947, ≥98% (HPLC)
SMILES string
c1ccc(nc1)-c2n[nH]cc2-c3ccnc4ccccc34
InChI key
IBCXZJCWDGCXQT-UHFFFAOYSA-N
InChI
1S/C17H12N4/c1-2-6-15-13(5-1)12(8-10-19-15)14-11-20-21-17(14)16-7-3-4-9-18-16/h1-11H,(H,20,21)
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Gene Information
human ... TGFBR1(7046)
Biochem/physiol Actions
LY-364947 是转化生长因子-β I 型受体激酶（TGF-β RI，ALK5）的选择性 ATP 竞争性抑制剂，IC50 = 59 nM。它对相关激酶的效力要差得多，TGF-β RII 的 IC50 = 400 nM ，混合谱系激酶 7（MLK-7）（MAP 激酶信号途径中的激酶，与 TGF-β RII 密切相关）的 IC50 = 1400 nM。LY-364947 抑制 NIH 3T3 小鼠成纤维细胞中 TGF-β 依赖性细胞生长（IC50 = 81 nM）。
转化生长因子-β 型 I 受体激酶（ALK5）抑制剂
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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