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Merck
CN

L6543

Lacto-N-neo-tetraose

synthetic, ≥85% (HPLC)

别名:

β-D-Gal-(1→4)-β-D-GlcNAc-(1→3)-β-D-Gal-(1→4)-D-Glc, LNnT

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关于此项目

经验公式（希尔记法）:
C26H45NO21
化学文摘社编号:
13007-32-4
分子量:
707.63
NACRES:
NA.25
PubChem Substance ID:
24896438
UNSPSC Code:
12352201
MDL number:
MFCD00467190

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产品名称

Lacto-N-neo-tetraose, synthetic, ≥85% (HPLC)

InChI key

RBMYDHMFFAVMMM-UHFFFAOYSA-N

SMILES string

CC(=O)NC1C(O)C(OC2OC(CO)C(O)C(O)C2O)C(CO)OC1OC3C(O)C(CO)OC(OC(C(O)CO)C(O)C(O)C=O)C3O

InChI

1S/C26H45NO21/c1-7(33)27-13-17(39)22(47-25-19(41)18(40)15(37)10(4-30)43-25)12(6-32)45-24(13)48-23-16(38)11(5-31)44-26(20(23)42)46-21(9(35)3-29)14(36)8(34)2-28/h2,8-26,29-32,34-42H,3-6H2,1H3,(H,27,33)

biological source

synthetic

assay

≥85% (HPLC)

form

powder

storage temp.

2-8°C

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存储类别

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCBM9050V
SLBH0057V
SLBF3582V
SLBF3582
SLBB8736

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Erina Yoshida et al.
Glycobiology, 22(3), 361-368 (2011-09-20)
The breast-fed infant intestine is often colonized by particular bifidobacteria, and human milk oligosaccharides (HMOs) are considered to be bifidogenic. Recent studies showed that Bifidobacterium longum subsp. infantis can grow on HMOs as the sole carbon source. This ability has
Stephen A Fleming et al.
Frontiers in neuroscience, 14, 770-770 (2020-09-10)
Human milk contains a unique profile of oligosaccharides (OS) and preliminary evidence suggests they impact brain development. The objective of this study was to assess the impact of bovine and/or human milk oligosaccharides (HMO) (2'-fucosyllactose and Lacto-N-neotetraose) on cognition, brain
Alexandra S Tauzin et al.
Microbiome, 8(1), 141-141 (2020-10-03)
Despite the importance of the mucosal interface between microbiota and the host in gut homeostasis, little is known about the mechanisms of bacterial gut colonization, involving foraging for glycans produced by epithelial cells. The slow pace of progress toward understanding
R M Erney et al.
Journal of pediatric gastroenterology and nutrition, 30(2), 181-192 (2000-03-04)
A complex array of free oligosaccharides is a distinctive compositional feature of human milk. Although these oligosaccharides have been studied for several years, their variability and distribution have not been systematically studied, and their nutritional and functional roles have not
Laetitia Renaudie et al.
Carbohydrate research, 339(3), 693-698 (2004-03-12)
The lacto-N-neotetraose tetrasaccharide was synthesized on a new dendrimeric support, based on polyethylene glycol. Starting from 1-thio-beta-D-lactose, the trisaccharide (2-acetamido-2-deoxy-beta-D-glucopyranosyl)-(1-->3)-O-beta-D-galactopyranosyl-(1-->4)-1-thio-beta-D-glucopyranose was obtained using Neisseria meningitidis beta-(1-->3)-N-acetylglucosaminyltransferase according to a soluble synthesis approach, bound on the support and galactosylated using the
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Review of O-Linked Glycoproteins

O-Linked glycoproteins are usually large proteins with a molecular mass of >200 kDa. Glycosylation generally occurs in high-density clusters and may represent as much as 50-80% of the overall mass.

O-连接糖蛋白回顾

O-连接糖蛋白通常是分子量>200kDa的大蛋白。糖基化通常发生在高密度簇上，并可占总量的50-80%。

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