跳转至内容
Merck
CN

L6785

Sigma-Aldrich

乳酸胱氨酸

≥90% (HPLC), powder, proteosome inhibitor

登录查看公司和协议定价

关于此项目

经验公式（希尔记法）:
C15H24N2O7S
CAS Number:
133343-34-7
分子量:
376.43
MDL编号:
MFCD01076525
UNSPSC代码:
12352200
PubChem化学物质编号:
24896445
NACRES:
NA.77

主要文件

查看所有文档
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

Product Name

乳酸胱氨酸, ≥90% (HPLC)

质量水平

200

方案

≥90% (HPLC)

表单

powder

效能

4 nM Ki (proteasome inhibitor)

溶解性

water: 10 mg/mL, clear, colorless

储存温度

−20°C

SMILES字符串

CC(C)[C@H](O)[C@]1(NC(=O)[C@H](C)[C@@H]1O)C(=O)SC[C@H](NC(C)=O)C(O)=O

InChI

1S/C15H24N2O7S/c1-6(2)10(19)15(11(20)7(3)12(21)17-15)14(24)25-5-9(13(22)23)16-8(4)18/h6-7,9-11,19-20H,5H2,1-4H3,(H,16,18)(H,17,21)(H,22,23)/t7-,9+,10+,11+,15-/m1/s1

InChI key

DAQAKHDKYAWHCG-RWTHQLGUSA-N

相关类别

一般描述

乳酸菌素作为一种抗生素，是链霉菌的代谢物。

应用

使用乳胞素：
  • 作为蛋白酶体抑制剂，抑制蛋白质降解
  • 抑制细胞蛋白酶体活性，为活细胞成像
  • 阻断人单核细胞来源的树突状细胞(MoDC)中蛋白酶体蛋白水解长达24小时
  • 对动物进行单侧注射，诱导黑纹状体病变

生化/生理作用

乳酸菌素在小鼠神经母细胞瘤细胞系中具有抑制细胞周期发育、刺激分化等作用。它可以作为Clasto-乳胞素β-内酯的前体。细胞可透过性和不可逆蛋白酶体抑制剂(Ki = 4nM)。抑制NF-kB的活化(IC50 = 10mM)。在neuro2A小鼠神经母细胞瘤细胞中诱导神经突生长。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCT8161
MKCL8926
MKCF1940
MKCC0039
MKBV3037V

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Evolution of extra-nigral damage predicts behavioural deficits in a rat proteasome inhibitor model of Parkinson's disease
Vernon A C, et al.
PLoS ONE, 6(2), e17269-e17269 (2011)
Dallas S Shi et al.
The Journal of clinical investigation, 124(9), 3757-3766 (2014-07-26)
The proteasome inhibiter bortezomib has been successfully used to treat patients with relapsed multiple myeloma; however, many of these patients become thrombocytopenic, and it is not clear how the proteasome influences platelet production. Here we determined that pharmacologic inhibition of
Cannabinoid receptor-induced neurite outgrowth is mediated by Rap1 activation through Galphao/i-triggered proteasomal degradation of Rap1GAPII
Jordan J D, et al.
The Journal of Biological Chemistry, 280(12), 11413-11421 (2005)
The development and pharmacology of proteasome inhibitors for the management and treatment of cancer
Ruggeri B, et al.
Advances in Pharmacology, 57(13), 91-135 (2009)
Mechanistic Studies on the Inactivation of the Proteasome by Lactacystin A CENTRAL ROLE FOR clasto-LACTACYSTIN beta-LACTONE
Dick L R, et al.
The Journal of Biological Chemistry, 271(13), 7273-7276 (1996)
查看所有相关文献

商品

Irreversible Inhibitors

Discover definitions and uses for irreversible inhibitors including the types of irreversible inhibitors: suicide inhibitors, heavy metal inhibitors, and time-dependent inhibitors.

DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research

DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research

相关内容

Protease Inhibitor Selection: Avoid Protein Loss in Sample Prep

Select different protease inhibitor types based on your needs to prevent protein degradation during isolation and characterization and safeguard proteins in sample prep.

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持