产品名称
单磷酰脂质A 来源于肠沙门氏菌 明尼苏达血清型 Re 595（Re 突变体）, lyophilized powder, TLR ligand tested
biological source
Salmonella enterica (serotype minnesota Re 595 Re mutant)
form
lyophilized powder
impurities
<0.2% Ketodeoxyoctonate (KDO)
shipped in
ambient
storage temp.
2-8°C
Quality Level
Application
脂质A分子组成脂质膜，锚定革兰氏阴性细菌产生的内毒素的核心组分。 脂质A分子可诱导免疫反应。 在结构上，脂质A分子由两个葡萄糖胺单元组成，两者具有不同的物种依赖性脂肪酰链数、同一性和磷酸化程度。
来自肠道沙门氏菌血清型明尼苏达Re 595的单磷酰脂质A可用于比较评估不同LPA分子和类似物中特定结构的抗原性。
来自肠道沙门氏菌血清型明尼苏达Re 595的单磷酰脂质A可用于比较评估不同LPA分子和类似物中特定结构的抗原性。
Biochem/physiol Actions
脂多糖（LPS）是革兰氏阴性细菌细胞壁的特征成分。LPS及其脂质A部分通过Toll样受体4（TLR4）刺激先天免疫系统的细胞，TLR4是Toll样受体蛋白家族的成员，该家族可识别常见的病原体相关分子模式（PAMP）。
脂质A具有免疫刺激佐剂活性，包括巨噬细胞、T细胞和B细胞活化。 研究表明，脂质A对Th2的刺激性比对Th1的大。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Tarik A Khan et al.
Science advances, 2(3), e1501371-e1501371 (2016-03-22)
High-throughput antibody repertoire sequencing (Ig-seq) provides quantitative molecular information on humoral immunity. However, Ig-seq is compromised by biases and errors introduced during library preparation and sequencing. By using synthetic antibody spike-in genes, we determined that primer bias from multiplex polymerase
Subhashini Jagu et al.
Vaccine, 28(28), 4478-4486 (2010-05-04)
Immunization with L1 as pentavalent capsomeres or virus-like particles (VLPs) generates high and long-lived titers of neutralizing antibodies and protection primarily against the human papillomavirus (HPV) type from which the vaccine was derived. Conversely, vaccination with L2 minor capsid protein
Tyler J Van De Voort et al.
Journal of immunotherapy (Hagerstown, Md. : 1997), 36(1), 29-40 (2012-12-06)
In this study, an agonistic anti-CD40 monoclonal antibody was combined with monophosphoryl lipid A (MPL), a nontoxic derivative of lipopolysaccharide and agonist of toll-like receptor-4, to assess the immunomodulatory and antitumor synergy between the 2 agents in mice. Anti-CD40 was
S Hutchison et al.
Veterinary immunology and immunopathology, 216, 109912-109912 (2019-08-26)
Melanoma in humans and canines is an aggressive and highly metastatic cancer. The mucosal forms in both species share genetic and histopathologic features, making dogs a valuable spontaneous disease animal model. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of
Yanjun Zhang et al.
Antiviral research, 165, 11-22 (2019-03-02)
Respiratory syncytial virus (RSV) infection causes significant disease in the lower respiratory tract of young children, and there is currently no licensed vaccine to prevent RSV infection. The F glycoprotein is considered a major antigenic target for RSV vaccine development.
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