Name: LFM-A13
Brand: SIGMA

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About This Item

经验公式（希尔记法）:

C₁₁H₈Br₂N₂O₂

CAS Number:

244240-24-2

分子量:

360.00

MDL编号:

MFCD09878279

UNSPSC代码:

12352200

PubChem化学物质编号:

329817646

NACRES:

NA.77

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质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

white to tan

溶解性

DMSO: ≥19 mg/mL

储存温度

2-8°C

SMILES字符串

C\C(O)=C(/C#N)C(=O)Nc1cc(Br)ccc1Br

InChI

1S/C11H8Br2N2O2/c1-6(16)8(5-14)11(17)15-10-4-7(12)2-3-9(10)13/h2-4,16H,1H3,(H,15,17)/b8-6-

InChI key

UVSVTDVJQAJIFG-VURMDHGXSA-N

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生化/生理作用

LFM-A13 is a potent and selective inhibitor of Bruton′s tyrosine kinase (BTK)

LFM-A13 is an inhibitor of the nonreceptor tyrosine kinase Bruton′s tyrosine kinase (Btk), a new molecular target for treatment of B-cell lymphoma and autoimmune disorders. LFMA13 inhibited recombinant BTK with an IC50 value of 2.5microM with 100-fold lower inhibitory activity against a number of other protein kinases including JAK1, JAK2, EGFR, IRK, IKK, and CDK1, 2 and 3, as well as several other related kinases

特点和优势

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.