L7035
Clasto-乳胞素 β-内酯
≥95% (HPLC), irreversible proteasome inhibitor, film
别名:
(1R,4R,5S)-1-[(1S)-1-羟基-2-甲基丙基]-4-甲基-6-氧杂-2-氮杂双环[3.2.0]庚烷-3,7-二酮, Omuralide
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关于此项目
经验公式（希尔记法）:
C10H15NO4
化学文摘社编号:
分子量:
213.23
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
Clasto-乳胞素 β-内酯,
方案
≥95% (HPLC)
质量水平
表单
film
溶解性
DMSO: soluble 25 mg/mL
储存温度
−20°C
SMILES字符串
[H][C@@]12OC(=O)[C@@]1(NC(=O)[C@@H]2C)[C@@H](O)C(C)C
InChI
1S/C10H15NO4/c1-4(2)6(12)10-7(15-9(10)14)5(3)8(13)11-10/h4-7,12H,1-3H3,(H,11,13)/t5-,6+,7+,10-/m1/s1
InChI key
FWPWHHUJACGNMZ-NBBQQVJHSA-N
应用
Clasto-乳胞素 β-内酯用作蛋白酶体抑制剂。
Clasto-乳胞素β-内酯已用作蛋白降解抑制剂以检测其对小鼠记忆改善的作用。它还用作人卵巢上皮(HOSE)细胞和树突状细胞(DC)的蛋白酶体抑制剂。
生化/生理作用
Clasto-乳胞素β-内酯(cLβL)由乳胞素(Lactacystin)合成。它具有细胞可透过性。cLβL可作用于蛋白酶体β -亚基X的N端苏氨酸。还可通过作用于β -型亚基的N-苏氨酸残基，抑制嗜盐古菌Haloferax volcanii的20S蛋白酶体活性。
细胞渗透性和不可逆蛋白酶体抑制剂。乳胞素作为染色体断裂-乳胞素 β 的前体-内酯。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Sue-Hyun Lee et al.
Science (New York, N.Y.), 319(5867), 1253-1256 (2008-02-09)
Reactivated memory undergoes a rebuilding process that depends on de novo protein synthesis. This suggests that retrieval is dynamic and serves to incorporate new information into preexisting memories. However, little is known about whether or not protein degradation is involved
Coordinated regulation of dendrite arborization by epigenetic factors CDYL and EZH2
Qi C, et al.
The Journal of Neuroscience, 34(13), 4494-4508 (2014)
Kristen Willeumier et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 26(44), 11333-11341 (2006-11-03)
The ubiquitin proteasome system, generally known for its function in protein degradation, also appears to play an important role in regulating membrane trafficking. A role for the proteasome in regulating presynaptic release and vesicle trafficking has been proposed for invertebrates
Florian Vogel et al.
Traffic (Copenhagen, Denmark), 8(9), 1205-1214 (2007-07-17)
Intracellular trafficking of viral movement proteins (MPs) in plants has mainly been studied using Tobacco mosaic virus MP30 (TMV MP30) as a model system. Because of the limitations of TMV MP30 expression in Arabidopsis thaliana, these studies have mostly been
L R Dick et al.
The Journal of biological chemistry, 271(13), 7273-7276 (1996-03-29)
Lactacystin is a Streptomyces metabolite that inhibits cell cycle progression and induces differentiation in a murine neuroblastoma cell line. The cellular target of lactacystin is the 20 S proteasome, also known as the multicatalytic proteinase complex, an essential component of
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