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Merck
CN

L7134

人促黄体激素释放激素 乙酸盐

≥98% (HPLC), powder

别名:

Gonadoliberin, Gonadotropin releasing hormone, LH-RH

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关于此项目

经验公式（希尔记法）:
C55H75N17O13
化学文摘社编号:
71447-49-9
分子量:
1182.29
NACRES:
NA.32
PubChem Substance ID:
329817648
UNSPSC Code:
51111800
MDL number:
MFCD00133489

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产品名称

人促黄体激素释放激素 乙酸盐, ≥98% (HPLC), powder

InChI

1S/C55H75N17O13.2C2H4O2/c1-29(2)19-38(49(80)67-37(9-5-17-60-55(57)58)54(85)72-18-6-10-43(72)53(84)62-25-44(56)75)66-46(77)26-63-47(78)39(20-30-11-13-33(74)14-12-30)68-52(83)42(27-73)71-50(81)40(21-31-23-61-35-8-4-3-7-34(31)35)69-51(82)41(22-32-24-59-28-64-32)70-48(79)36-15-16-45(76)65-36;2*1-2(3)4/h3-4,7-8,11-14,23-24,28-29,36-43,61,73-74H,5-6,9-10,15-22,25-27H2,1-2H3,(H2,56,75)(H,59,64)(H,62,84)(H,63,78)(H,65,76)(H,66,77)(H,67,80)(H,68,83)(H,69,82)(H,70,79)(H,71,81)(H4,57,58,60);2*1H3,(H,3,4)/t36-,37-,38-,39-,40-,41-,42-,43-;;/m0../s1

SMILES string

CC(O)=O.CC(O)=O.CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc4c[nH]cn4)NC(=O)[C@@H]5CCC(=O)N5)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N6CCC[C@H]6C(=O)NCC(N)=O

InChI key

QOVPLTBEZAJSHY-VIRDRFNDSA-N

assay

≥98% (HPLC)

form

powder

mol wt

Mr 1182.33

UniProt accession no.

P01148

storage temp.

−20°C

Quality Level

200

Gene Information

human ... GNRH1(2796)

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Application

Luteinizing hormone releasing hormone human acetate salt has been used:
  • for synchronization of the ovulations
  • for pre-absorption of the anti-GnRH antibody in staining procedures
  • to study pituitary sensitivity to GnRH in presence of endocrine disrupting compound

Biochem/physiol Actions

Hypothalamic peptide that stimulates release of gonadotrophins from anterior pituitary, thus regulating reproductive functions.
Stimulates release of gonadotrophins from anterior pituitary.

Other Notes

Lyophilized from 0.5% acetic acid
free peptide
pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H360

Hazard Classifications

Repr. 1B

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000251730
0000251730
0000134445
0000091270
059M4818V

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Histological characterization of gonadotropin-releasing hormone
(GnRH) in the hypothalamus of the South American plains
vizcacha (Lagostomus maximus)
Veronica, et.la
Journal of Molecular Histology (2011)
Developmental Programming: Impact of Prenatal Exposure to Bisphenol-A and Methoxychlor on Steroid Feedbacks in Sheep
Bachir Abi Salloum
Toxicology and Applied Pharmacology (2013)
Verónica Berta Dorfman et al.
Biology of reproduction, 89(5), 115-115 (2013-10-04)
In mammals, elevated levels of progesterone (P4) throughout gestation maintain a negative feedback over the hypothalamic-hypophyseal-gonadal (H-H-G) axis, avoiding preovulatory follicular growth and preventing ovulation. Recent studies showed that in the South American plains vizcacha (Lagostomus maximus) folliculogenesis progresses to
Nicholas A Levis et al.
Ecology and evolution, 5(7), 1405-1411 (2015-04-22)
Phenotypic plasticity is commonplace, and plasticity theory predicts that organisms should often evolve mechanisms to detect and respond to environmental cues that accurately predict future environmental conditions. Here, we test this prediction in tadpoles of spadefoot toads, Spea multiplicata. These
L A MacConell et al.
Neuroendocrinology, 70(4), 246-254 (1999-10-26)
Activin is essential for the regulation of normal mammalian reproductive function at both the pituitary and gonadal levels. However, its central actions in the control of the hypothalamic-pituitary-gonadal axis remain largely unexplored. The present study aims to determine whether activin
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