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Merck
CN

L7134

Sigma-Aldrich

人促黄体激素释放激素 乙酸盐

≥98% (HPLC), powder

别名:

Gonadoliberin, Gonadotropin releasing hormone, LH-RH

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关于此项目

经验公式(希尔记法):
C55H75N17O13
化学文摘社编号:
分子量:
1182.29
MDL编号:
UNSPSC代码:
51111800
PubChem化学物质编号:
NACRES:
NA.32
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质量水平

方案

≥98% (HPLC)

表单

powder

分子量

Mr 1182.33

UniProt登记号

储存温度

−20°C

SMILES字符串

CC(O)=O.CC(O)=O.CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc4c[nH]cn4)NC(=O)[C@@H]5CCC(=O)N5)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N6CCC[C@H]6C(=O)NCC(N)=O

InChI

1S/C55H75N17O13.2C2H4O2/c1-29(2)19-38(49(80)67-37(9-5-17-60-55(57)58)54(85)72-18-6-10-43(72)53(84)62-25-44(56)75)66-46(77)26-63-47(78)39(20-30-11-13-33(74)14-12-30)68-52(83)42(27-73)71-50(81)40(21-31-23-61-35-8-4-3-7-34(31)35)69-51(82)41(22-32-24-59-28-64-32)70-48(79)36-15-16-45(76)65-36;2*1-2(3)4/h3-4,7-8,11-14,23-24,28-29,36-43,61,73-74H,5-6,9-10,15-22,25-27H2,1-2H3,(H2,56,75)(H,59,64)(H,62,84)(H,63,78)(H,65,76)(H,66,77)(H,67,80)(H,68,83)(H,69,82)(H,70,79)(H,71,81)(H4,57,58,60);2*1H3,(H,3,4)/t36-,37-,38-,39-,40-,41-,42-,43-;;/m0../s1

InChI key

QOVPLTBEZAJSHY-VIRDRFNDSA-N

基因信息

human ... GNRH1(2796)

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Amino Acid Sequence

Glp-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2

应用

Luteinizing hormone releasing hormone human acetate salt has been used:
  • for synchronization of the ovulations
  • for pre-absorption of the anti-GnRH antibody in staining procedures
  • to study pituitary sensitivity to GnRH in presence of endocrine disrupting compound

生化/生理作用

Hypothalamic peptide that stimulates release of gonadotrophins from anterior pituitary, thus regulating reproductive functions.
Stimulates release of gonadotrophins from anterior pituitary.

包装

Bottomless glass bottle. Contents are inside inserted fused cone.

其他说明

Lyophilized from 0.5% acetic acid
free peptide
pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2

象形图

Health hazard

警示用语:

Danger

危险声明

预防措施声明

危险分类

Repr. 1B

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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L A MacConell et al.
Neuroendocrinology, 70(4), 246-254 (1999-10-26)
Activin is essential for the regulation of normal mammalian reproductive function at both the pituitary and gonadal levels. However, its central actions in the control of the hypothalamic-pituitary-gonadal axis remain largely unexplored. The present study aims to determine whether activin
ERa and GnRH co-localize in the hypothalamic neurons of the South American plains vizcacha, Lagostomus maximus (Rodentia, Caviomorpha)
Pablo Ignacio
Journal of Molecular Histology (2017)
Histological characterization of gonadotropin-releasing hormone
(GnRH) in the hypothalamus of the South American plains
vizcacha (Lagostomus maximus)
Veronica, et.la
Journal of Molecular Histology (2011)
Verónica Berta Dorfman et al.
Biology of reproduction, 89(5), 115-115 (2013-10-04)
In mammals, elevated levels of progesterone (P4) throughout gestation maintain a negative feedback over the hypothalamic-hypophyseal-gonadal (H-H-G) axis, avoiding preovulatory follicular growth and preventing ovulation. Recent studies showed that in the South American plains vizcacha (Lagostomus maximus) folliculogenesis progresses to
Nicholas A Levis et al.
Ecology and evolution, 5(7), 1405-1411 (2015-04-22)
Phenotypic plasticity is commonplace, and plasticity theory predicts that organisms should often evolve mechanisms to detect and respond to environmental cues that accurately predict future environmental conditions. Here, we test this prediction in tadpoles of spadefoot toads, Spea multiplicata. These

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