L7140
S-乳酰谷胱甘肽
≥90% (TLC)
别名:
SLG
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关于此项目
经验公式（希尔记法）:
C13H21N3O8S
化学文摘社编号:
分子量:
379.39
NACRES:
NA.26
PubChem Substance ID:
UNSPSC Code:
12352209
MDL number:
InChI
1S/C13H21N3O8S/c1-6(17)13(24)25-5-8(11(21)15-4-10(19)20)16-9(18)3-2-7(14)12(22)23/h6-8,17H,2-5,14H2,1H3,(H,15,21)(H,16,18)(H,19,20)(H,22,23)/t6-,7-,8-/m0/s1
SMILES string
C[C@H](O)C(=O)SC[C@H](NC(=O)CC[C@H](N)C(O)=O)C(=O)NCC(O)=O
InChI key
VDYDCVUWILIYQF-FXQIFTODSA-N
assay
≥90% (TLC)
form
powder
color
white
application(s)
detection
storage temp.
−20°C
General description
适用于作为乙二醛酶 II 的底物。
Application
- 非靶向代谢组学提供了关于从天然乳清发酵剂中分离的瑞士乳杆菌在甲基乙二醛介导褐变中影响的新见解。: 该研究利用非靶向代谢组学来考察S-乳酰谷胱甘肽在甲基乙二醛介导的褐变反应中的作用，重点介绍了其在食品加工和安全中的影响Galimberti S et al., 2023).
- 多组学分析揭示了在产蛋鸡中植物乳植杆菌预防LPS诱导的输卵管炎的分子调节网络。: 该研究确认了S-乳酰谷胱甘肽在预防LPS诱导的输卵管炎的分子调节网络中的作用，重点强调了其在鸟类健康和生物技术应用中的重要性（Song D et al., 2023）。
- 猪肉烤制过程中来源于乙二醛和甲基乙二醛的晚期糖基化终产物的分析。: 该研究考察了来源于乙二醛和甲基乙二醛的晚期糖基化终产物（AGE）的形成，关注了S-乳酰谷胱甘肽在肉类烤制过程中减轻这些反应的作用（Eggen MD et al., 2021）。
Biochem/physiol Actions
S-乳酰谷胱甘肽（SLG）用于研究细菌和植物中谷胱甘肽依赖性乙二醛酶系统和 KefGB 钾外排泵。S-乳酰谷胱甘肽也可用于研究癌症中嘧啶从头合成的抑制。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
T Pourmotabbed et al.
The Journal of biological chemistry, 261(30), 14240-14244 (1986-10-25)
Formaldehyde dehydrogenases isolated from several different biological sources have been reported to catalyze the NAD+-dependent oxidative acylation of glutathione by methylglyoxal to form S-pyruvylglutathione, suggesting the involvement of this enzyme in the metabolism of methylglyoxal. However, formaldehyde dehydrogenase from bovine
A Klimes et al.
Canadian journal of microbiology, 52(9), 816-822 (2006-11-18)
A glyoxalase I gene homologue (VdGLO1) was identified in the vascular wilt fungus Verticillium dahliae by sequence tag analysis of genes expressed during resting structure development. The results of the current study show that the gene encodes a putative 345
L G Edwards et al.
Leukemia research, 20(1), 17-26 (1996-01-01)
The inhibition of human leukaemia 60 cell growth by S-D-lactoylglutathione in vitro is mediated by the inhibtion of de novo pyridimine synthesis. When S-D-lactoylglutathione was added to human leukaemia 60 cells in culture, it was hydrolysed by thiolesterase activity to
Nathan F Wenzel et al.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 9(4), 429-438 (2004-04-07)
Cytosolic glyoxalase 2 (GLX2-2) from Arabidopsis thaliana is a metalloenzyme that has been shown to bind a mixture of Zn, Fe, or Mn when produced in cells grown in rich media. In an effort to prepare metal-enriched samples, GLX2-2 was
Kwang Sik Suh et al.
Free radical research, 52(6), 712-723 (2018-05-25)
Methylglyoxal (MG) is a reactive α-oxoaldehyde that increases under diabetic conditions and subsequently contributes to the complications associated with this disease. Piceatannol is a naturally occurring analogue of resveratrol that possesses multiple biological functions. The present study investigated the effects
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