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Merck
CN

L7418

LAAM 盐酸盐

≥98% (HPLC), solid

别名:

α-l-acetylmethadol hydrochloride, (1S)-2-[(2S)-2-(dimethylamino)propyl]-1-ethyl-2,2-diphenylethyl acetate hydrochloride, MK-790 hydrochloride, ORLAAM hydrochloride, levomethadyl acetate hydrochloride

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关于此项目

经验公式（希尔记法）:
C23H32ClNO2
化学文摘社编号:
43033-72-3
分子量:
389.96
UNSPSC Code:
12352202
PubChem Substance ID:
329817651
MDL number:
MFCD01723736

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InChI

1S/C23H31NO2.ClH/c1-6-22(26-19(3)25)23(17-18(2)24(4)5,20-13-9-7-10-14-20)21-15-11-8-12-16-21;/h7-16,18,22H,6,17H2,1-5H3;1H/t18-,22-;/m0./s1

SMILES string

Cl.CC[C@H](OC(C)=O)C(C[C@H](C)N(C)C)(c1ccccc1)c2ccccc2

InChI key

UXBPQRGCVJOTNT-COBSGTNCSA-N

assay

≥98% (HPLC)

form

solid

drug control

USDEA Schedule II; kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada, kontrollierte Droge in Deutschland

Gene Information

human ... OPRM1(4988)

color

white

solubility

H2O: >5 mg/mL

storage temp.

2-8°C

Biochem/physiol Actions

LAAM hydrochloride is μ opioid receptor agonist.
LAAM hydrochloride is μ opioid receptor agonist. LAAM hydrochloride is a DEA-controlled substance, which has a slow onset, but a long duration of action. LAAM is a useful tool for studying opiate tolerance and cross-reactivity with other μ opioid receptor agonists.

Other Notes

DEA Schedule II

Legal Information

German
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.

English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 2 Oral - Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

法规信息

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分析证书(COA)

Lot/Batch Number
047K4612

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Erich F Wedam et al.
Archives of internal medicine, 167(22), 2469-2475 (2007-12-12)
Levomethadyl acetate, methadone hydrochloride, and buprenorphine hydrochloride are equally effective treatments for opioid dependence. Each blocks the human ether-a-go-go-related gene (hERG)-associated channel in vitro and represents a risk for QT prolongation. To compare the effects of 3 known hERG-associated channel
M Douglas Anglin et al.
The journal of behavioral health services & research, 36(2), 267-282 (2008-11-22)
Levo-alpha-acetylmethadol maintenance (LAAM) was compared to methadone maintenance (MM) on the behavioral performance of 315 heroin addicts before, during, and after 12 months of fully subsidized treatment. Assessments of drug use, criminal behavior, HIV risk behaviors, and employment and residential
Séverine Crettol et al.
Pharmacology, 80(4), 304-311 (2007-08-11)
Methadone and L-alpha-acetylmethadol (LAAM) are used as treatment for opiate addiction. Using a cellular model, we aimed to determine if methadone, LAAM and their main metabolites are substrates of the human P-glycoprotein transporter (P-gp), which is encoded by the ABCB1
No opiate substitutes for the masses of IDUs.
Jon Cohen
Science (New York, N.Y.), 329(5988), 165-167 (2010-07-10)
Lisa R Gerak et al.
Physiology & behavior, 93(1-2), 20-26 (2007-09-04)
Polydrug abuse remains a common problem among opioid abusers as well as patients in opioid maintenance programs. Although cocaine abuse has been reported in patients receiving methadone, the incidence of cocaine use in patients receiving l-alpha-acetylmethadol (LAAM) has not been
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