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Merck
CN

L7418

Sigma-Aldrich

LAAM 盐酸盐

≥98% (HPLC), solid

别名:

α-l-acetylmethadol hydrochloride, (1S)-2-[(2S)-2-(dimethylamino)propyl]-1-ethyl-2,2-diphenylethyl acetate hydrochloride, MK-790 hydrochloride, ORLAAM hydrochloride, levomethadyl acetate hydrochloride

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关于此项目

经验公式（希尔记法）:
C23H32ClNO2
化学文摘社编号:
43033-72-3
分子量:
389.96
MDL编号:
MFCD01723736
UNSPSC代码:
12352202
PubChem化学物质编号:
329817651

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方案

≥98% (HPLC)

表单

solid

药品控制

USDEA Schedule II; kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada

颜色

white

溶解性

H2O: >5 mg/mL

储存温度

2-8°C

SMILES字符串

Cl.CC[C@H](OC(C)=O)C(C[C@H](C)N(C)C)(c1ccccc1)c2ccccc2

InChI

1S/C23H31NO2.ClH/c1-6-22(26-19(3)25)23(17-18(2)24(4)5,20-13-9-7-10-14-20)21-15-11-8-12-16-21;/h7-16,18,22H,6,17H2,1-5H3;1H/t18-,22-;/m0./s1

InChI key

UXBPQRGCVJOTNT-COBSGTNCSA-N

基因信息

human ... OPRM1(4988)

生化/生理作用

LAAM hydrochloride is μ opioid receptor agonist.
LAAM hydrochloride is μ opioid receptor agonist. LAAM hydrochloride is a DEA-controlled substance, which has a slow onset, but a long duration of action. LAAM is a useful tool for studying opiate tolerance and cross-reactivity with other μ opioid receptor agonists.

其他说明

DEA Schedule II

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险分类

Acute Tox. 2 Oral - Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
047K4612

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Mohit P Chopra et al.
Pharmacology, biochemistry, and behavior, 90(4), 787-796 (2008-07-01)
Pooled self-report and physiological data from 32 male and 15 female methadone or levo-alpha-acetyl methadol (LAAM) maintained volunteers were retrospectively analyzed for individual differences in response to naloxone (0.15 mg/70 kg, IM) and placebo at 20 and 40 min post-injection.
Michael J Mancino et al.
The American journal on addictions, 19(2), 169-177 (2010-02-19)
This randomized clinical trial retrospectively examined the effect of post-traumatic stress disorder (PTSD) and contingency management (CM) on cocaine use in opioid and cocaine dependent individuals maintained on high or low-dose LAAM randomly assigned to CM or a yoked-control condition.
Bradley T Conner et al.
The journal of behavioral health services & research, 36(2), 189-198 (2008-09-05)
This study empirically tested one component of a comprehensive model of the role of religiosity and spirituality (R/S) in drug treatment that is presented as a companion article in this special issue. Data collected from individuals dependent on heroin receiving
Roberta Freddi et al.
Progress in neuro-psychopharmacology & biological psychiatry, 33(3), 419-426 (2009-01-28)
One group of six male control rats [21 months old] and one group of six male rats of the same age, singularly stored in a cage, and treated with acetyl-l-carnitine-HCl (ALCAR: 60 mg/kg/day/p.o.) for six months were tested in the
H Wieneke et al.
European journal of medical research, 14(1), 7-12 (2009-03-05)
Due to potential proarrhythmic side-effects levo-alpha-Acetylmethadol (LAAM) is currently not available in EU countries as maintenance drug in the treatment of opiate addiction. However, recent studies and meta-analyses underline the clinical advantages of LAAM with respect to the reduction of
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