L7757
利多卡因
≥98% (GC), powder, neuroprotective agent
别名:
2-二乙氨基-N-（2,6-二甲苯基）乙酰胺, 利多卡因, 赛洛卡因
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关于此项目
经验公式（希尔记法）:
C14H22N2O
化学文摘社编号:
分子量:
234.34
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
205-302-8
MDL number:
Form:
powder
产品名称
利多卡因, powder
form
powder
Quality Segment
SMILES string
CCN(CC)CC(=O)Nc1c(C)cccc1C
InChI
1S/C14H22N2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,5-6,10H2,1-4H3,(H,15,17)
InChI key
NNJVILVZKWQKPM-UHFFFAOYSA-N
Gene Information
human ... CYP1A2(1544), SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)
rat ... Scnn1a(25122)
General description
Lidocaine is a local anesthetic and an effective antiarrhythmia agent. It occurs as solutions of crystalline colorless solid for injections, that has a short half-life within plasma.
Application
Lidocaine may be used for drug testing and for voltage clamp experiments.
Biochem/physiol Actions
Lidocaine, a neuroprotective agent, mediates blockage of sodium (Na+) channels. It prevents the influx of sodium ions leading to depolarization of sodium channels and metabolically inactivated in liver. Lidocaine has positive effect on cerebral ischemia. It is also used in the treatment of ventricular tachycardia. Lidocaine is an efficient anesthetic agent in ophthalmic surgeries as it is highly potent and has good tissue penetrability.
Na+通道阻滞剂；IB类抗心律失常药。
Na+通道阻滞剂；在肠胃外给药后可迅速被吸收的IB类抗心律失常药。
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警示词
Warning
危险代码
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
怎么回事？
WGK 3
闪点 (F)
Not applicable
闪点 (°C)
Not applicable
PPE（个人防护设备）
dust mask type N95 (US), Eyeshields, Faceshields, Gloves