L7795
左西替利嗪 二盐酸盐
≥98% (HPLC)
别名:
左西替利嗪 二盐酸盐, (-)-二盐酸西替利嗪; 2-[2-[4-[(R)-（4-氯苯基）-苯基-甲基]哌嗪-1-基]乙氧基]乙酸 二盐酸盐
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关于此项目
经验公式（希尔记法）:
C21H25ClN2O3·2HCl
化学文摘社编号:
分子量:
461.81
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
左西替利嗪 二盐酸盐, ≥98% (HPLC)
InChI key
PGLIUCLTXOYQMV-GHVWMZMZSA-N
SMILES string
Cl.Cl.OC(=O)COCCN1CCN(CC1)[C@H](c2ccccc2)c3ccc(Cl)cc3
InChI
1S/C21H25ClN2O3.2ClH/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26;;/h1-9,21H,10-16H2,(H,25,26);2*1H/t21-;;/m1../s1
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
solubility
H2O: ≥23 mg/mL
storage temp.
room temp
Quality Level
Gene Information
human ... HRH1(3269)
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Application
左西替利嗪二盐酸盐已被用作薄层色谱优化的标准品，并用于亚临界流体色谱-串联质谱分析的外消旋西替利嗪标准品的制备中。
Biochem/physiol Actions
左旋西替利嗪是一种非镇静型组胺H1受体拮抗剂; 西替利嗪的活性异构体
盐酸左西替利嗪是一种非镇静抗组胺药。它是一种组胺H1受体拮抗剂，西替利嗪的活性异构体。左西替利嗪对H1受体具有较高的生物利用度、高亲和力和占据度。
General description
左西替利嗪二盐酸盐是西替利嗪的R-对映体，可用于治疗季节性过敏性鼻炎和慢性特发性荨麻疹。肝脏可代谢14％的左西替利嗪，而其余的可通过尿液被排出体外。左西替利嗪对组胺的反应相对于西替利嗪较高。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
A double-blind, randomized, single-dose, crossover comparison of levocetirizine with ebastine, fexofenadine, loratadine, mizolastine, and placebo: suppression of histamine-induced wheal-and-flare response during 24 hours in healthy male subjects
Grant JA, et al.
Annals of Allergy, Asthma & Immunology, 88(2), 190-197 (2002)
Levocetirizine does not prolong the QT/QTc interval in healthy subjects: results from a thorough QT study
Hulhoven R, et al.
European Journal of Pharmacology, 63(11), 1011-1017 (2007)
Nurul Atika Razali et al.
BMC complementary and alternative medicine, 18(1), 217-217 (2018-07-18)
Histamine is a well-known mediator involved in skin allergic responses through up-regulation of pro-inflammatory cytokines. Antihistamines remain the mainstay of allergy treatment, but they were found limited in efficacy and associated with several common side effects. Therefore, alternative therapeutic preferences
Rapid chiral separation of racemic cetirizine in human plasma using subcritical fluid chromatography-tandem mass spectrometry
Eom HY, et al.
Journal of Pharmaceutical and Biomedical Analysis, 117, 380-389 (2016)
Dhagla R Choudhary et al.
Scientia pharmaceutica, 80(3), 779-787 (2012-09-26)
A fast-dissolving film containing levocetirizine, a non-sedative antihistamine drug, was developed using pullulan, xanthan gum, propylene glycol, and tween 80 as the base materials. The drug content of the prepared films was within an acceptable limit as prescribed by the
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