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Merck
CN

L8543

DL -羊毛硫氨酸

≥98% (TLC)

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关于此项目

经验公式(希尔记法):
C6H12N2O4S
化学文摘社编号:
分子量:
208.24
UNSPSC Code:
12352209
NACRES:
NA.26
EC Number:
221-676-5
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产品名称

DL -羊毛硫氨酸, ≥98% (TLC)

form

powder

color

white

SMILES string

S(CC(N)C(=O)O)CC(N)C(=O)O

InChI key

DWPCPZJAHOETAG-UHFFFAOYSA-N

InChI

1S/C6H12N2O4S/c7-3(5(9)10)1-13-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)

assay

≥98% (TLC)

solubility

1 M HCl: soluble

application(s)

detection

Quality Level

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Application


  • Synthesis of the lantibiotic lactocin S using peptide cyclizations on solid phase.:采用创新方法合成肽基抗生素,如乳酸链球菌素S(lactocin S),过程中利用dl-羊毛硫氨酸形成重要的硫醚交联,提高多肽的活性和稳定性(Ross et al., 2010)。

  • Cystathionine gamma-lyase of Streptomyces phaeochromogenes.:分离和鉴定一种处理胱硫醚的酶,其中dl-羊毛硫氨酸被作为结构类似物,揭示其细菌生理学作用和生物技术应用潜力(Nagasawa et al., 1984)。

  • The availability of dl-lanthionine for the promotion of growth in young rats when added to a cystine- and methionine-deficient diet.:该古早研究探讨dl-羊毛硫氨酸的营养价值,评估其取代生长饮食必需氨基酸的能力,有助了解其在营养补充剂中的潜在用途(Jones et al., 1948)。

Biochem/physiol Actions

羊毛硫氨酸是一种非典型氨基酸,是胱氨酸的单硫化物类似物。羊毛硫氨酸是一组肽类抗生素的成分,称为羊毛硫抗生素,其中包括乳链菌肽和枯草菌素。

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Wolfgang M Müller et al.
Biochemistry, 50(39), 8362-8373 (2011-09-13)
Lantibiotics are peptide antibiotics, realizing their unique secondary structure by posttranslational modifications, the most important one being the formation of the characteristic amino acid lanthionine. Like other ribosomal peptide antibiotics, they are synthesized with an N-terminal leader peptide important for
Jun-ichi Nagao et al.
Current pharmaceutical biotechnology, 12(8), 1221-1230 (2011-04-08)
Lantibiotics are ribosomally synthesized, post-translationally modified, peptide antibiotics containing unusual amino acids such as dehydrated amino acids and lanthionine. These unusual amino acids impose conformational constraints on the peptide and contribute to the biological activity and high physicochemical stability of
Steffen F Hansen et al.
Journal of dairy science, 103(7), 5874-5881 (2020-05-12)
During heat treatment of milk, β-lactoglobulin (β-LG) associates with the milk fat globule membrane (MFGM). The objective of this study was to examine different binding types that could be involved in this process. First, we tested the thiol-disulfide bond interchange
Ayşe Ökesli et al.
Journal of the American Chemical Society, 133(34), 13753-13760 (2011-07-21)
Lantibiotics are ribosomally synthesized and post-translationally modified antimicrobial peptides that are characterized by the thioether cross-linked amino acids lanthionine (Lan) and methyllanthionine (MeLan). Cinnamycin is a 19 amino acid lantibiotic that contains one Lan and two MeLan. Cinnamycin also contains
Antonino Mavaro et al.
The Journal of biological chemistry, 286(35), 30552-30560 (2011-07-16)
Nisin is a posttranslationally modified antimicrobial peptide containing the cyclic thioether amino acids lanthionine and methyllanthionine. Although much is known about its antimicrobial activity and mode of action, knowledge about the nisin modification process is still rather limited. The dehydratase

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