L9668
Lidoflazine
≥98% (HPLC), powder
别名:
4-[4,4-Bis(4-fluorophenyl)butyl]-N-(2,6-dimethylphenyl)-1-piperazineacetamide
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white
溶解性
DMSO: ≥10 mg/mL
储存温度
2-8°C
SMILES字符串
Cc1cccc(C)c1NC(=O)CN2CCN(CCCC(c3ccc(F)cc3)c4ccc(F)cc4)CC2
InChI
1S/C30H35F2N3O/c1-22-5-3-6-23(2)30(22)33-29(36)21-35-19-17-34(18-20-35)16-4-7-28(24-8-12-26(31)13-9-24)25-10-14-27(32)15-11-25/h3,5-6,8-15,28H,4,7,16-21H2,1-2H3,(H,33,36)
InChI key
ZBIAKUMOEKILTF-UHFFFAOYSA-N
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相关类别
生化/生理作用
HERG calcium channel blocker
Lidoflazine is an antianginal calcium channel blocker that carries a significant risk of QT interval prolongation and ventricular arrhythmia. It prolongs QT interval by blocking HERG channel. IC50 < 0.1 μM
特点和优势
This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Thomas P Zonneveld et al.
The Cochrane database of systematic reviews, 7, CD007858-CD007858 (2018-07-20)
Stroke is an important cause of death and disability worldwide. Since high blood pressure is an important risk factor for stroke and stroke recurrence, drugs that lower blood pressure might play an important role in secondary stroke prevention. To investigate
J Jacobsson et al.
Transplant international : official journal of the European Society for Organ Transplantation, 6(5), 281-284 (1993-01-01)
The effect of adding a 21-aminosteroid, U74500A, and a Ca2+ antagonist, lidoflazine, alone and together to UW solution was assessed in a rat liver preservation model. Following preservation, the livers were reperfused using a closed circuit, and the release of
S G De Hert et al.
Journal of cardiothoracic and vascular anesthesia, 11(1), 42-48 (1997-02-01)
The present study evaluated the effects of the nucleoside transport inhibitor, lidoflazine, at a dose of 1 mg/kg, on left ventricular function. Patients were randomly assigned to receive either lidoflazine or saline in a double-blind manner. A university hospital. The
G J Grover et al.
The Journal of pharmacology and experimental therapeutics, 268(1), 90-96 (1994-01-01)
The goal of this study was to determine the cardioprotective profile for the nucleoside transport inhibitor 2-(aminocarboxyl)-N-(4-amino-2,6-dichlorophenyl)-4-[5,5-bis(4- fluorophenyl)pentyl]-1-piperazinylacetamide trihydrochloride-2,5 hydrate (R 75231) in isolated rat hearts and whether its protective effects are caused by adenosine A1 activation. R 75231 increased
Liver preservation with lidoflazine and the University of Wisconsin solution: a dose-finding study.
J Jacobsson et al.
Transplantation, 56(2), 472-475 (1993-08-01)
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