L9668
Lidoflazine
≥98% (HPLC), powder
别名:
4-[4,4-Bis(4-fluorophenyl)butyl]-N-(2,6-dimethylphenyl)-1-piperazineacetamide
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关于此项目
经验公式（希尔记法）:
C30H35F2N3O
化学文摘社编号:
分子量:
491.62
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
222-312-8
MDL number:
产品名称
Lidoflazine, ≥98% (HPLC), powder
InChI
1S/C30H35F2N3O/c1-22-5-3-6-23(2)30(22)33-29(36)21-35-19-17-34(18-20-35)16-4-7-28(24-8-12-26(31)13-9-24)25-10-14-27(32)15-11-25/h3,5-6,8-15,28H,4,7,16-21H2,1-2H3,(H,33,36)
InChI key
ZBIAKUMOEKILTF-UHFFFAOYSA-N
SMILES string
Cc1cccc(C)c1NC(=O)CN2CCN(CCCC(c3ccc(F)cc3)c4ccc(F)cc4)CC2
assay
≥98% (HPLC)
form
powder
color
white
solubility
DMSO: ≥10 mg/mL
storage temp.
2-8°C
Quality Level
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相关类别
Biochem/physiol Actions
HERG calcium channel blocker
Lidoflazine is an antianginal calcium channel blocker that carries a significant risk of QT interval prolongation and ventricular arrhythmia. It prolongs QT interval by blocking HERG channel. IC50 < 0.1 μM
Features and Benefits
This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
H J Rogove et al.
Critical care medicine, 23(1), 18-25 (1995-01-01)
To assess survival after cardiac arrest and to determine whether age is an independent determinant of late mortality or poor neurologic outcome. Analyses using results of Brain Resuscitation Clinical Trial I (1979 to 1984) and Brain Resuscitation Clinical Trial II
S G De Hert et al.
Acta anaesthesiologica Scandinavica, 38(5), 479-485 (1994-07-01)
A significant central-to-peripheral arterial pressure gradient may exist during and after cardiopulmonary bypass (CPB). The etiology and mechanisms of this phenomenon remain controversial. We studied the pressure gradient between aorta, brachial artery and radial artery in 68 patients, scheduled for
G J Grover et al.
The Journal of pharmacology and experimental therapeutics, 268(1), 90-96 (1994-01-01)
The goal of this study was to determine the cardioprotective profile for the nucleoside transport inhibitor 2-(aminocarboxyl)-N-(4-amino-2,6-dichlorophenyl)-4-[5,5-bis(4- fluorophenyl)pentyl]-1-piperazinylacetamide trihydrochloride-2,5 hydrate (R 75231) in isolated rat hearts and whether its protective effects are caused by adenosine A1 activation. R 75231 increased
J Jacobsson et al.
Transplant international : official journal of the European Society for Organ Transplantation, 6(5), 281-284 (1993-01-01)
The effect of adding a 21-aminosteroid, U74500A, and a Ca2+ antagonist, lidoflazine, alone and together to UW solution was assessed in a rat liver preservation model. Following preservation, the livers were reperfused using a closed circuit, and the release of
S G De Hert et al.
Journal of cardiothoracic and vascular anesthesia, 11(1), 42-48 (1997-02-01)
The present study evaluated the effects of the nucleoside transport inhibitor, lidoflazine, at a dose of 1 mg/kg, on left ventricular function. Patients were randomly assigned to receive either lidoflazine or saline in a double-blind manner. A university hospital. The
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