M0199
Mdivi-1
≥98% (HPLC), powder, mitochondrial division DRP inhibitor
别名:
3-(2,4-二氯-5-甲氧基苯）-2,3-二羟基-2-硫基-4（1H）-喹唑啉酮, 3-(2,4-二氯-5-甲氧基苯）-2-硫烷基-4（3H）-喹唑啉酮
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C15H10Cl2N2O2S
化学文摘社编号:
分子量:
353.22
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
Mdivi-1, ≥98% (HPLC), powder
SMILES string
COc1cc(N2C(S)=Nc3ccccc3C2=O)c(Cl)cc1Cl
InChI
1S/C15H10Cl2N2O2S/c1-21-13-7-12(9(16)6-10(13)17)19-14(20)8-4-2-3-5-11(8)18-15(19)22/h2-7H,1H3,(H,18,22)
InChI key
NZJKEVWTYMOYOR-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: >20 mg/mL
shipped in
wet ice
storage temp.
−20°C
Quality Level
Application
Mdivi-1用于：
- 胚胎胸主动脉A7r5细胞，抑制细胞迁移和增殖
- 研究少突胶质前体细胞（OPC）中线粒体网络重塑和活性氧（ROS）产生
- 诱导肺成纤维细胞的线粒体损伤
Biochem/physiol Actions
Mdivi-1是线粒体DRP（发动蛋白相关GTP酶）分裂选择性抑制剂以及线粒体分裂发动蛋白（Dnm1）抑制剂。线粒体融合和分裂在细胞凋亡调节中有很重要的作用。Mdivi-1是线粒体分裂发动蛋白首选抑制剂。基本上，Mdivi-1代表了一系列用于治疗中风，心肌梗塞和神经退行性疾病的药物。
Mdivi-1是线粒体DRP（发动蛋白相关GTP酶）分裂选择性抑制剂；线粒体分裂发动蛋白（Dnm1）抑制剂。
Features and Benefits
该化合物是细胞凋亡研究的特色产品。点击此处 ，查看更多细胞凋亡精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问sigma.com/discover-bsm。
General description
线粒体分裂抑制剂1（Mdivi-1）是喹唑啉酮衍生物，具有细胞渗透性。能穿越血脑屏障，在心、脑缺血再灌注损伤中引发保护功能。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Impaired mitophagy leads to cigarette smoke stress-induced cellular senescence: implications for chronic obstructive pulmonary disease
Ahmad T, et al.
Faseb Journal, 29(7), 2912-2929 (2015)
To mdivi-1 or not to mdivi-1: Is that the question?
Smith G and Gallo G
Developmental neurobiology, 77(11), 1260-1268 (2017)
Da Zhang et al.
PloS one, 13(5), e0197266-e0197266 (2018-05-17)
Hypoxia-mediated pancreatic beta cell death is one of the main causes of pancreatic beta celldeath, which leads to the loss of functional pancreatic beta cell mass and type 1 diabetes andtype 2 diabetes.However, the molecular mechanisms that control life and
The putative Drp1 inhibitor mdivi-1 is a reversible mitochondrial complex I inhibitor that modulates reactive oxygen species
Bordt EA, et al.
Developmental Cell, 40(6), 583-594 (2017)
Haixia Xu et al.
Frontiers in physiology, 11, 113-113 (2020-03-03)
Doxorubicin is a valuable antineoplastic drug although its clinical use is greatly hindered by its severe cardiotoxicity with dismal target therapy available. Luteolin is a natural product extracted from vegetables and fruits with a wide range of biological efficacies including
商品
Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.
Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持