M024080
ssH-Linker
configured for PerkinElmer, configured for Polygen
别名:
9,11-Dioxa-2-aza-10-phosphatridecanoic acid, 10-[bis(1-methylethyl)amino]-13-cyano-, 2-[[(4-methoxyphenyl)diphenylmethyl]amino]ethyl este
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关于此项目
经验公式（希尔记法）:
C38H53N4O5P
分子量:
676.83
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (31P-NMR), ≥98.0% (reversed phase HPLC)
Storage temp.:
−20°C
type
for DNA synthesis
Quality Level
product line
Proligo Reagents
assay
≥98% (31P-NMR), ≥98.0% (reversed phase HPLC)
compatibility
configured for PerkinElmer, configured for Polygen
storage temp.
−20°C
SMILES string
COc1ccc(cc1)C(NCCOC(=O)NCCCCCCOP(OCCC#N)N(C(C)C)C(C)C)(c2ccccc2)c3ccccc3
InChI
1S/C38H53N4O5P/c1-31(2)42(32(3)4)48(47-29-16-25-39)46-28-15-7-6-14-26-40-37(43)45-30-27-41-38(33-17-10-8-11-18-33,34-19-12-9-13-20-34)35-21-23-36(44-5)24-22-35/h8-13,17-24,31-32,41H,6-7,14-16,26-30H2,1-5H3,(H,40,43)
InChI key
VTFLXOVDKJUHER-UHFFFAOYSA-N
General description
ssH-linker comprises an internal carbamate group attached to the MMT-protected amino group via a short spacer. The carbamate moiety facilitates the cleavage of the MMT group under mildly acidic conditions while increasing the stability of the MMT group during the deprotection of the oligonucleotide with ammonia. The carbamate group also enhances the reactivity of the amino group through a neighbor group effect, and thereby accelerates conjugations to amino reactive modifiers and reporters. The MMT-group of ssH-linker serves as an excellent purification handle after the oligonucleotide synthesis in trityl-on mode, similar to the DMT-group of conventional oligonucleotides. The MMT-group is cleaved under very mild conditions in aqueous acetic acid (10% glacial acetic acid in the water, 20 min. room temp.) Alternatively, the MMT-group can be cleaved on the synthesis instrument with an acidic deblock solution to enable on-support labeling protocols.
Legal Information
This product is covered under US Patent Number 7,491,857
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| M024080-0.25G | 04061833402344 |
| M024080-1G | 04061822381438 |