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Merck
CN

M0443

米氮平

≥98% (HPLC), 5-HT2 antagonist; 5-HT3, H1 and α2 antagonist, powder

别名:

1,2,3,4,10,14b-Hexahydro-2-methylpyrazino[2,1-a]pyrido[2,3-c][2]benzazepine

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关于此项目

经验公式（希尔记法）:
C17H19N3
化学文摘社编号:
85650-52-8
分子量:
265.35
UNSPSC Code:
12352200
PubChem Substance ID:
24724531
NACRES:
NA.77
MDL number:
MFCD00865427

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产品名称

米氮平, ≥98% (HPLC)

SMILES string

CN1CCN2C(C1)c3ccccc3Cc4cccnc24

InChI key

RONZAEMNMFQXRA-UHFFFAOYSA-N

InChI

1S/C17H19N3/c1-19-9-10-20-16(12-19)15-7-3-2-5-13(15)11-14-6-4-8-18-17(14)20/h2-8,16H,9-12H2,1H3

assay

≥98% (HPLC)

form

powder

color

white

solubility

DMSO: 8 mg/mL, clear

Quality Level

100

Gene Information

human ... ADRA2A(150), ADRA2B(151), ADRA2C(152), DRD2(1813), DRD3(1814), DRD4(1815), HRH1(3269), HTR1A(3350), HTR2A(3356), HTR2C(3358), HTR7(3363)
mouse ... Slc6a2(20538)
rat ... Adra1a(29412), Drd1a(24316), Drd2(24318), Htr1a(24473), Htr2a(29595), Htr2c(25187), Slc6a3(24898), Slc6a4(25553)

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相关类别

Biochem/physiol Actions

Mirtazapine is a noradrenergic and specific serotonergic antidepressant (NaSSA). Mirtazapine agonizes selective adrenergic and serotonergic receptors so that both NE release and 5-HT1A mediated serotonergic signaling are increased.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302,H336

Hazard Classifications

Acute Tox. 4 Oral - STOT SE 3

target_organs

Central nervous system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000456489
0000456489
0000427574
0000427574
0000414267

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M A Raji et al.
The Annals of pharmacotherapy, 35(9), 1024-1027 (2001-09-28)
Depression in patients with Alzheimer disease is a treatable cause of functional decline, caregiver burden, and mortality. It is often associated with severe weight loss, insomnia, and anxiety. These symptoms independently and collaboratively further worsen the prognosis of these vulnerable
B Milne et al.
British journal of pharmacology, 155(8), 1264-1278 (2008-09-23)
Ultra-low doses of opioid receptor antagonists augment spinal morphine antinociception and block the induction of tolerance. Considering the evidence demonstrating functional and physical interactions between the opioid and alpha(2)-adrenoceptors, this study investigated whether ultra-low doses of alpha(2)-adrenoceptor antagonists also influence
S A Anttila et al.
CNS drug reviews, 7(3), 249-264 (2001-10-19)
The novel antidepressant mirtazapine has a dual mode of action. It is a noradrenergic and specific serotonergic antidepressant (NaSSA) that acts by antagonizing the adrenergic alpha2-autoreceptors and alpha2-heteroreceptors as well as by blocking 5-HT2 and 5-HT3 receptors. It enhances, therefore
David E Kemp
Journal of affective disorders, 169 Suppl 1, S34-S44 (2014-12-24)
The most commonly used pharmacologic therapies for bipolar depression are mood stabilizers, atypical antipsychotics, and antidepressants. This paper reviews common side effects associated with these medications and provides recommendations for managing adverse medication effects in clinical practice. Narrative review based
Hun Soo Chang et al.
Journal of neural transmission (Vienna, Austria : 1996), 122(1), 59-68 (2014-12-03)
Hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis is among the most consistent neuroendocrine abnormalities in major depressive disorder (MDD). The peptide adrenocorticotropin hormone (ACTH) mediates HPA axis function during stress and is encoded by the proopiomelanocortin (POMC) gene polycistronically. After screening
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