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COO原产地证书/COA分析证书

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M0639

6α-甲基泼尼松龙

Name: 6α-甲基泼尼松龙
Brand: SIGMA

≥98%

别名:

11β,17α,21-三羟基-6α-甲基-1,4-孕甾二烯-3,20-二酮, 6α-甲基-11β,17α,21-三羟基-1,4-孕甾二烯-3,20-二酮, 甲基强的松龙, 甲基泼尼松龙

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About This Item

经验公式（希尔记法）:

C₂₂H₃₀O₅

CAS Number:

83-43-2

分子量:

374.47

Beilstein:

2340300

EC 号:

201-476-4

MDL编号:

MFCD00010591

UNSPSC代码:

12352200

PubChem化学物质编号:

24896564

NACRES:

NA.77

生物来源

synthetic

质量水平

200

无菌性

non-sterile

方案

≥98%

表单

powder

溶解性

chloroform: methanol (1:1): 50 mg/mL, clear, colorless to faintly yellow

应用

cell analysis

运输

ambient

储存温度

room temp

SMILES字符串

[H][C@@]12C[C@H](C)C3=CC(=O)C=C[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO

InChI

1S/C22H30O5/c1-12-8-14-15-5-7-22(27,18(26)11-23)21(15,3)10-17(25)19(14)20(2)6-4-13(24)9-16(12)20/h4,6,9,12,14-15,17,19,23,25,27H,5,7-8,10-11H2,1-3H3/t12-,14-,15-,17-,19+,20-,21-,22-/m0/s1

InChI key

VHRSUDSXCMQTMA-PJHHCJLFSA-N

基因信息

human ... NR3C1(2908)
rat ... Nr3c1(24413)

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应用

6α-Methylprednisolone has been used:

to stimulate RPMI 8226.1 cells in order to govern the expression of human interleukin-10 (IL-10) gene
to induce depletion of CD14⁺ CD16⁺ monocytes
to study its effect on behavioral and sensory afferent hypersensitivity

生化/生理作用

Methylprednisolone is a glucocorticoid having anti-inflammatory and immunosuppressive actions. It is useful in treating skin diseases, allergies, multiple sclerosis, asthma, rheumatic disorders, chronic obstructive pulmonary disease, croup and cancer.