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M0883

4-Methylumbelliferyl acetate

Name: 4-Methylumbelliferyl acetate
Brand: SIGMA

esterase substrate

别名:

MU-Ac

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关于此项目

经验公式（希尔记法）:

C₁₂H₁₀O₄

化学文摘社编号:

2747-05-9

分子量:

218.21

UNSPSC Code:

12352204

NACRES:

NA.32

PubChem Substance ID:

24896576

EC Number:

220-386-6

Beilstein/REAXYS Number:

189667

MDL number:

MFCD00006865

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Quality Level

100

assay

≥98% (TLC)

form

powder

mp

149-150 °C (lit.)

solubility

chloroform: 100 mg/mL, clear, colorless

fluorescence

λ_ex 312 nm in methanol, λ_ex 360 nm; λ_em 499 nm (Reaction product)

storage temp.

−20°C

SMILES string

CC(=O)Oc1ccc2C(C)=CC(=O)Oc2c1

InChI

1S/C12H10O4/c1-7-5-12(14)16-11-6-9(15-8(2)13)3-4-10(7)11/h3-6H,1-2H3

InChI key

HXVZGASCDAGAPS-UHFFFAOYSA-N

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Chemoprevention of benzene-induced bone marrow and pulmonary genotoxicity.

H G Raj et al.

Teratogenesis, carcinogenesis, and mutagenesis, 21(2), 181-187 (2001-02-27)

Our earlier studies documented the ability of 7,8-diacetoxy-4-methylcoumarin (DAMC) to cause irreversible inhibition of cytochrome P-450 linked mixed function oxidases (MFO) mediated by membrane bound DAMC: protein transacetylase. Since P-450 catalyzed oxidation of benzene is crucial to its toxic effects

Can superoxide organic chemistry be observed within the liposomal bilayer?

A A Frimer et al.

Free radical biology & medicine, 20(6), 843-852 (1996-01-01)

--2-(Dimethylamino) fluorene (1a) and 5-benzoyloxy-2,3,7,8,12,13,17,18-octaethylporphyrin (4) react with superoxide anion radical (generated from KO2/18-crown-6 polyether) in aprotic media. Yet, when incorporated into the lipid bilayer of dimyristoyl phosphatidylcholine liposomes, these two substrates are inert to superoxide, generated enzymatically (xanthine oxidase/acetaldehyde)

Enzyme kinetic studies in cell populations using fluorogenic substrates and flow cytometric techniques.

J V Watson

Cytometry, 1(2), 143-151 (1980-09-01)

Fluorescence identifies an alkaline cell in turtle urinary bladder.

M L Graber et al.

The American journal of physiology, 250(1 Pt 2), F159-F168 (1986-01-01)

Intracellular pH (pHi) of turtle bladder mucosal cells was studied by the trapped fluorescent indicator technique. Bladders efficiently accumulated and converted 4-methylumbelliferyl acetate to its pH-sensitive derivative 4-methylumbelliferone (4MU). Excited at the pH-indifferent wavelength 334 nm, bladders fluoresced a uniform

Specificities of calreticulin transacetylase to acetoxy derivatives of 3-alkyl-4-methylcoumarins: effect on the activation of nitric oxide synthase.

Abha Kathuria et al.

Bioorganic & medicinal chemistry, 17(4), 1550-1556 (2009-02-03)

Calreticulin Transacetylase (CRTAase) catalyzes the transfer of acetyl groups from polyphenolic acetates (PAs) to the receptor proteins and modulates their biological activities. CRTAase was conveniently assayed by the irreversible inhibition of cytosolic glutathione S-transferase (GST) by the model acetoxycoumarin, 7,8-diacetoxy-4-methylcoumarin

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全球贸易项目编号

货号	GTIN
M0883-5G	04061834037545

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