M1195
Metolazone
≥98% (HPLC), solid
别名:
7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide
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关于此项目
经验公式（希尔记法）:
C16H16ClN3O3S
化学文摘社编号:
分子量:
365.83
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
241-539-3
MDL number:
color
white
form
solid
InChI
1S/C16H16ClN3O3S/c1-9-5-3-4-6-14(9)20-10(2)19-13-8-12(17)15(24(18,22)23)7-11(13)16(20)21/h3-8,10,19H,1-2H3,(H2,18,22,23)
InChI key
AQCHWTWZEMGIFD-UHFFFAOYSA-N
SMILES string
CC1Nc2cc(Cl)c(cc2C(=O)N1c3ccccc3C)S(N)(=O)=O
assay
≥98% (HPLC)
solubility
DMSO: >5 mg/mL
Quality Level
Gene Information
human ... SLC12A1(6557), SLC12A3(6559)
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Biochem/physiol Actions
Inhibitor of thiazide-sensitive Na+-Cl- cotransporter; antihypertensive; moderate "loop" diuretic.
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
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María Castañeda-Bueno et al.
American journal of physiology. Renal physiology, 299(5), F1111-F1119 (2010-08-20)
Little is known about the residues that control the binding and affinity of thiazide-type diuretics for their protein target, the renal Na(+)-Cl(-) cotransporter (NCC). Previous studies from our group have shown that affinity for thiazides is higher in rat (rNCC)
Gabriella Pridjian et al.
The Journal of pharmacology and experimental therapeutics, 318(3), 1027-1032 (2006-05-24)
Preeclampsia is a disorder that continues to exact a significant toll with respect to maternal morbidity and mortality as well as fetal wastage. Furthermore, the treatment of this disorder has not changed significantly in 50 years and is unsatisfactory. The
Guangli Wei et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 845(1), 169-173 (2006-08-16)
A rapid, sensitive and accurate liquid chromatographic-tandem mass spectrometric method is described for the determination of metolazone in human blood. Metolazone was extracted from blood using ethyl acetate and separated on a C18 column interfaced with a triple quadrupole tandem
Robert J Hoyer et al.
American journal of hematology, 82(5), 409-413 (2007-02-28)
Refractory pleural effusions present a challenging management problem and are associated with a poor prognosis in patients with primary systemic amyloidosis (AL). We report a series of four patients with AL who presented with bilateral pleural effusions that were refractory
Lynda Blue et al.
European journal of heart failure, 7(3), 351-361 (2005-02-19)
This article examines the emerging role of the heart failure nurse and the responsibilities and educational and training requirements surrounding such a role. There may be variations in the role and its responsibilities in different health care settings. However the
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Voltage-gated sodium channels are present in most excitable cell membranes and play an important role in generating action potentials.
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