M1275
萘普生 钠
synthetic (organic), 98.0-102.0%, Prostaglandin H synthase 1 and 2 inhibitor, powder
别名:
(S)-6-甲氧基-α-甲基-2-萘乙酸 钠盐
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关于此项目
经验公式（希尔记法）:
C14H13NaO3
化学文摘社编号:
分子量:
252.24
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
247-486-2
MDL number:
产品名称
萘普生 钠, 98.0-102.0%
InChI
1S/C14H14O3.Na/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10;/h3-9H,1-2H3,(H,15,16);/q;+1/p-1/t9-;/m0./s1
InChI key
CDBRNDSHEYLDJV-FVGYRXGTSA-M
SMILES string
[Na+].COc1ccc2cc(ccc2c1)[C@H](C)C([O-])=O
biological source
synthetic (organic)
assay
98.0-102.0%
form
powder
solubility
water: 100 mg/mL, clear to slightly hazy, colorless to faintly yellow
originator
Bayer
Quality Level
Gene Information
human ... PTGS1(5742), PTGS2(5743)
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Application
萘普生钠已被用于评价牛血清白蛋白和人血清白蛋白生物分子相互作用的热力学。其也被用于评价其降低脊髓背角神经元对伤害性膝关节旋转反应的效率。
Biochem/physiol Actions
环加氧酶（前列腺素 H 合成酶 1 和 2）抑制剂。
萘普生最好与血清白蛋白结合。与 R-异构体相比，萘普生的 S-异构体作为抗炎药物的潜力是前者的 28 倍。发现 R-异构体是一种肝脏毒素，可导致胃肠道疾病。
General description
萘普生属于苯乙酸类非甾体抗炎药 (NSAID)。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Repr. 1A
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
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