Name: Midostaurin hydrate
Brand: SIGMA

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About This Item

经验公式（希尔记法）:

C₃₅H₃₀N₄O₄ · xH₂O

CAS Number:

1217450-80-0

分子量:

570.64 (anhydrous basis)

MDL编号:

MFCD12828879

UNSPSC代码:

12352200

PubChem化学物质编号:

329817870

NACRES:

NA.77

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Product Name

Midostaurin hydrate, ≥98% (HPLC), solid

质量水平

100

方案

≥98% (HPLC)

表单

solid

颜色

off-white

溶解性

DMSO: >10 mg/mL

储存温度

−20°C

SMILES字符串

O.CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)[n@@H]3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8[n@H]2c7c35)N(C)C(=O)c9ccccc9

InChI

1S/C35H30N4O4.H2O/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38;/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40);1H2/t25-,26-,32-,35+;/m1./s1

InChI key

YEKDLUZCCDJYAJ-LJAYRLSQSA-N

生化/生理作用

Midostaurin is an inhibitor of tyrosine kinase, protein kinase C, and VEGF.

Midostaurin is an inhibitor of tyrosine kinase, protein kinase C, and VEGF. Midostaurin inhibits cell growth and phosphorylation of FLT3, STAT5, and ERK. Midostaurin is a potent inhibitor of a spectrum of FLT3 activation loop mutations.

特点和优势

This compound is featured on the PKC page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.