M1387
4-甲基吡唑 盐酸盐
alcohol dehydrogenase inhibitor
别名:
甲吡唑
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关于此项目
经验公式（希尔记法）:
C4H6N2 · HCl
化学文摘社编号:
分子量:
118.56
NACRES:
NA.77
PubChem Substance ID:
MDL number:
UNSPSC Code:
12352100
biological source
synthetic (organic)
Quality Segment
assay
≥95%
form
powder
mp
157-159 °C
solubility
methanol: 100 mg/mL, clear, colorless to yellow
storage temp.
2-8°C
SMILES string
Cl.Cc1cn[nH]c1
InChI
1S/C4H6N2.ClH/c1-4-2-5-6-3-4;/h2-3H,1H3,(H,5,6);1H
InChI key
PUCXJHNDMYZOHG-UHFFFAOYSA-N
Gene Information
human ... ADH1A(124), ADH1B(125), ADH1C(126)
Application
4-Methylpyrazole hydrochloride has been used:
- as a cytochrome P450 2E1 inhibitor
- as cytochrome P450 2E1 and alcohol dehydrogenase inhibitor in 1C11 neural progenitor cells
- to inhibit ethanol oxidation in VL-17A cells expressing alcohol dehydrogenase and HepG2 cells
Useful as an antidote in methanol and ethylene glycol poisoning.
Biochem/physiol Actions
醇脱氢酶抑制剂
4-Methylpyrazole (4MP) inhibits ethanol oxidation in liver microsomes. It also blocks the c-Jun N-terminal kinase (JNK) activation in in vitro liver injury models.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves